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赵明

姓名:赵明

性别:女

职称:教授

招生院所:药学院

招生类型:科学学位() 科学学位()

招生专业:药物化学() 药物化学()

研究方向名称:甾体多肽及其缀合物研究

电子信箱:

个人简介

      1960年生于北京,1995年毕业于北京医科大学药学院,获理学博士学位。1997年年被北京医科大学聘为副教授,2001年被北京大学药学院聘为教授,博士生导师。2006年至今为北京市特聘教授/多肽及小分子药物北京市重点实验室主任;2006-2012年为首都医科大学化学生物学与药学院副院长、2012-2014年为首都医科大学化学生物学与药学院常务副院长,2014年-至今为首都医科大学化学生物学与药学院院长,2007年为美国North Carolina大学访问教授、2009年至今为内源式预防药物教育部工程研究中心主任。2013年至今为生物医用材料北京实验室副主任,高雄医学大学客座教授。
        赵明致力于“基于氨基酸的寡肽药物”、“基于氨基酸的糖胺药物”等特色研究。主持完成了“1035”、“985”、“973”、“十一五”重大新药创制、国家自然科学基金(4项)、教育部博士点基金等研究项目。已发表国外SCI论文127篇(IF=401.375),8篇国际SCI论文被选为封面文章,申请国家发明专利415项(授权185项,公开48项,申请182项;获6项省部级科技进步奖。除参编10部国内专著外,受Wiley出版社邀请于2009年全球发行1部关于药物的生物分析的英文专著,被Wiley出版社推荐为该领域权威著作,并被国外前40名高校中的12所学校,如Stanford、Cambridge等大学图书馆收藏;英国University of East Anglia的Dr. Gerd Wagner 特别撰写书评发表在ChemMedChem上。由于抗骨质疏松新药研究的成绩, INTECH出版社邀请他为即将出版的New Findings in Osteoporosis (骨质疏松的新发现) 撰写了Modification of sex hormones with RGD-peptide: A strategy of improving HRT and other secondary osteoporosis therapy。在这本新书中, 这是唯一涉及抗骨质疏松新药研究的章节。此外,发表在英国化学会MedCheCom上的研究结果被BIONITY. COM网站报道、受国际杂志Expert Opin. Ther. Pat邀请对国际同行的专利进行专家评述、发表在ACS-NANO的文章被 ACS News Service Weekly PressPac: September 04, 2013报道,国内外媒体纷纷转载,发表在Nanoscale, Journal of Materials Chemistry, Medchemcomn,的药物研究的文章受邀作为封底文章。现为JMC、EJMC等刊物的审稿人,2010年被JMC评为Top tier reviewer。国际知名度逐步提高。
       1986年至今一直从事高等药学教育,站在教学第一线。独立承担3门本科生理论课和实验课、4门研究生理论课和实验课,理论授课240学时/年,实验课210学时/年。此外,承担药学专业实验课的管理和改革,实施精品药学教育,突出本科生和研究生实现大型仪器的操作,培养真才实学的创新和创业药学人才针对新药研发特点,坚持融合药物设计、合成、分析、活性筛选及药物作用机理研究到研究生的学位论文中,使硕士生的研究产出国家发明专利,博士生的研究产出国外SCI论文。研究生得到了全面训练。2002年至今培养59名博士生;175名硕士生。获2001年北京市教学成果一等奖和国家教学成果二等奖、2009年北京市教育教学成果二等奖、2013年北京市教育教学成果二等奖。
积极推动成果转化。5种产品上市、1个一类新药获临床批文、1个二类新药和1个四类新药正在申请新药证书。转让专利及技术7项,金额600余万;与企业联合培养人才3次,金额65万;

 

教育经历

1979-1983  北京医科大学, 药学院, 学士;

1991-1995  北京医科大学, 药学院, 博士;

1999-2000  台湾大学医学院药学系, 博士后;

2007       北卡大学, 访问教授;

 

工作经历

2014-至今  首都医科大学化学生物学与药学院,院长

2012-2014  首都医科大学化学生物学与药学院,常务副院长

2006-2012  首都医科大学化学生物学与药学院,副院长

2006-至今  北京市特聘教授,多肽及小分子药物北京市重点实验室主任

2001-2006  北京医科大学, 药学院教授, 博导;

1997-2001  北京医科大学, 药学院副教授;

 

重要学术论文

1.      Taiping Gan, Yuji Wang, Ming Zhao, Jianhui Wu, Jian Yang, Shiqi Peng.,5-(Bis(3-(2-hydroxyethyl)- 1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHI MHA ): showing a strategy of designing drug to block lung metastasis of tumors.Drug Design, Development and Therapy 2016, 10: 711-721. SCI

2.      Xi Hu, Ming Zhao, Yuji Wang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Xiangmin Li and Shiqi Peng ,Tetrahydro-b-carboline-3-carboxyl-thymopentin: a nano-conjugate for releasing pharmacophores to treat tumor and complications. J. Mater. Chem. B, 2016:4, 1384-1397. SCI

3.      Xu Wenyun, Zhao Ming, Wang Yuji, Zhu haimei, Wang Yaonan, Zhao Shurui, Wu Jianhui, Peng Shiqi ,Design, synthesis, and in vivo evaluations of benzyl Nω-nitro-Nα-(9H-pyrido[3,4-b]indole-3-carbonyl)-L-argininate as an apoptosis inducer capable of decreasing the serum concentration of P-selectin. Medchemcomm, 2016, 7, 1730 SCI

4.      Ning Song,Ming Zhao,Yuji Wang,Xi Hu,Jianhui Wu,Xueyun Jiang,Shan Li,Chunying Cui,Shiqi Peng1 Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of s180 mice treated with mtx/mit.. Drug Design Development & Therapy, Volume 10, 2701-2711. SCI

5.      Qiqi Feng, Ming Zhao*,Taiping Gan, Haimei Zhu, Yaonan Wang, Shurui Zhao, Yuji Wang, Jianhui Wu and Shiqi Peng*.DHDMIQK(KAP): a novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus. Journal of Materials Chemistry B. 2016. 4. 5991-6003. SCI

6.      Jianhui Wu1Yuji Wang1Yaonan Wang1Ming Zhao1,2Xiaoyi Zhang1Lin Gui1Shurui Zhao1Haimei Zhu1Jinghua Zhao1Shiqi Peng1 Cu2+-RGDFRGDS: exploring the mechanism and high efficacy of the nanoparticle in antithrombotic therapyInternational Journal of Nanomedicine 2015:10 29252938  4.383

7.       Yuji Wang, Jingcheng Tang, Haimei Zhu, Xueyun Jiang,Jiawang Liu,Wenyun Xu,HaipingMa,Qiqi Feng,Jianhui Wu,Ming Zhao, Shiqi Peng. Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis. International Journal of Nanomedicine  2015:10 114   4.383

8.       Shan Li,1 Yuji Wang,1 Feng Wang,1 Yaonan Wang,1 Xiaoyi Zhang,1 Ming Zhao,1,2 Qiqi Feng,1 Jianhui Wu,1 Shurui Zhao,1 Wei Wu,3 Shiqi Peng1Small molecule PZL318: forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis International Journal of Nanomedicine 2015:10 52735292  4.383

9.      Feng Wang a, Shan Li a, Yuji Wang a, Haimei Zhu a, Xiaoyi Zhang a, Ming Zhao *ab, Jianhui Wu a and Shiqi Peng *a Enantiomeric diketopiperazines: getting insight into the impact of the configuration on the conformation, nanoimage, u-PA inhibition and anti-metastatic activity†,Med. Chem. Commun., 2015, 6, 956-962  封面文章  2.495

10.   Xueyun Jiang, Yuji Wang, Haimei Zhu, Yaonan Wang, Ming Zhao, Shurui Zhao, Jianhui Wu, Shan Li, Shiqi Peng, Modifying tetramethyl-nitrophenyl-imidazoline with amino acids: Design, synthesis and 3D-QSAR for improving inflammatory pain therapy. Drug Des Dev Ther, 2015, 9, 2329-2342   . IF= 3.026

11.   Shan Li, Yuji Wang, Ming Zhao, Jianhui Wu, Shiqi Peng, BPIC: A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals. Bioorg Med Chem Lett, 2015, 25, 1146-1150.  IF=2.331

12.   Shuangling Chen, Yuji Wang, Shan Li, Yaonan Wang, Ming Zhao, Haimei Zhu, Jianhui Wu, Shiqi Peng, Poly-α,β-aspartyl-Arg-Gly-Asp-Phe: A novel polymeric nanomedicine. MedChemComm 2015, 6, 182-186.  2.495   封面文章

13.   Chunying Cui, Yuji Wang, Yaonan Wang, Junyu Yang, Jianzhong Xi, Ming Zhao, Shiqi Peng, Preparation and characterization of RGDS/nanodiamond as a vector for VEGF-siRNA delivery. J. Biomed. Nanotechnol., 2015, 11, 70-80. IF= 7.578

14.   Chunying Cui,a Yaonan Wang,a Wen Zhao,a Kaikai Yang,a Xueyun Jiang,a Shan Li,aMing Zhao,*ab Yuanbo Songc and Shiqi Peng*aRGDS covalently surfaced nanodiamond as a tumor targeting carrier of VEGF-siRNA: synthesis, characterization and bioassayJ. Mater. Chem. BDOI: 10.1039/c5tb01602a  IF= 4.726

15.   Minna Li,a Yuji Wang,a Yutong Yang,a Yeqing Gao,a Ming Zhao,*a,b Meiqing Zhenga and Shiqi Peng*aOximated ruthenium tris-bipyridyl complex:synthesis and luminescent response specifically for ClO in water containing multiple ionsDalton Trans., 2015, 44, 1407114076  4.197

16.   Hualong Yu, Shenghui Mei, Li Zhao, Ming Zhao,* Yuji Wang, Haimei Zhu,Yaonan Wang, Jianhui Wu, Chunying Cui, Wenyun Xu and Shiqi Peng*RGD-peptides modifying dexamethasone: to enhance the anti-inflammatory efficacy and limit the risk of osteoporosis†Med. Chem. Commun.,2015, 6, 1345-1351  2.495

17.   Wenhua Zhao,Yuji Wang, Weijia Hao, Ming Zhao*,ShiqiPeng*. Preparative isolation and purification of urolithins from the intestinal metabolites of pomegranate ellagitannins by high-speed of pomegranate ellagitannins by high-speed chromatography. Journal of Chromatography B, 2015, 990:111-117   2.694

18.   Haimei Zhu, Yuanbo Song, Yuji Wang,  Ming Zhao,* Yi Ren,Yaonan Wang, Shurui Zhao, Jianhui Wu, Shiqi Peng*, Design, synthesis and evaluation of novel π-π stacking nano-intercalator as anti-tumor agent†, Med. Chem. Commun  DOI: 10.1039/C5MD00507H   IF=2.495

19.   Xi Hu,Ming Zhao,* Yuji Wang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Xiangmin Li, and Shiqi Peng,*,Tetrahydro-β-carboline-3-carboxyl-thymopentin: A nano-conjugate for releasing pharmacophores to treat tumor and complications.Journal of Materials Chemistry B. DOI:10.1039/x0xx00000x  4.726

20.   Taiping Gan, Yuji Wang, Ming Zhao*,Jianhui Wu, Jian Yang, and Shiqi Peng*, 5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): Showing a strategy of designing drug to block lung metastasis of tumors, Drug Design, Development and Therapy.2015,已接受 3.028

21.   Nan Xie, Ke Feng, Bin Chen,b Ming Zhao, Li-Ping Zhang, Chen-Ho Tung, Li-Zhu Wu, Shiqi Peng, A modular designed copolymer with antithrombotic activity and imaging capability. ChemComm 2014, 50, 9535-9542.  IF= 6.718

22.   Fengxiang Du, Xiaoyi Zhang, Shan Li, Yaonan Wang, Meiqing Zheng, Yuji Wang, Shurui Zhao, Jianhui Wu, Lin Gui, Ming Zhao, Shiqi Peng, Mechanism of forming trimer, self-assembling nano-particle and inhibiting tumor growth of small molecule CIPPCT, MedChemComm 2014, 5,1634-1643. IF=2.626

23.   Wenhua Zhao, Yuji Wang, Weijia Hao, Ming Zhao, Shiqi Peng, In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-β-D-glucose plays a vital role in anti-tumour activity. BBRC, 2014, 445, 346-351. IF=2.281

24.   Nan Xie, Ke Feng, Bin Chen, Ming Zhao, Shiqi Peng, Liping Zhang, Chenho Tung, Lizhu Wu, Water-soluble copolymeric materials: switchable NIR two-photon fluorescence imaging agents for living cancer cells. J. Mater. Chem. B, 2014, 2, 502 - 510. IF= 6.626

25.   Shaoyin Wei, Wenxin Yao, Wenyuan Ji, Jiaqi Wei, Shiqi Peng, Qualitative and quantitative analysis of anthraquinones in rhubarbs by high performance liquid chromatography with diode array detector and mass spectrometry. Food Chem doi.org/10.1016/j.foodchem.2013.04.074.  3.334

26.   Wenjing Wang, Chenjie Fang, Xiaozhu Wang, Yuxi Chen, Wei Feng, Chunhua Yan, Ming Zhao, Shiqi Peng, Modifying mesoporous silica nano-particle to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy. Nanoscale 2013, 5, 6249 - 6253.  6.233   封面文章

27.    Haimei Zhu, Yuji Wang, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Guodong Yang, Shiqi Peng, Energy minimized crystal structures of P-selectins based on molecular dynamics simulation: Leading to two average structures capable of designing anti-thrombotic agents. MedChemComm 2013, 4, 1066 - 1072.  2.722

28.   Haimei Zhu, Yuji Wang, Yaonan Wang, Shurui Zhao, Ming Zhao, Lin Gui, Wenyun Xu, Xiangyun Amy Chen, Yanming Wang, Shiqi Peng, Folded conformation, cyclic pentamer, nano-structure and PAD4 binding mode of YW3-56. J Phys Chem C 2013, 117, 10070-10078.  4.814

29.   Shaoming Jin, Yaonan Wang, Haimei Zhu, Yuji Wang, Shurui Zhao, Ming Zhao,* Jiawang Liu,Jianhui Wu, Wen Gao, and Shiqi Peng,* Nanosized Aspirin-Arg-Gly-Asp-Val: elivery of Aspirin to Thrombus bythe Target Carrier Arg-Gly-Asp-Val etrapeptide. ACS Nano, 2013, 7 (9), 76647673. IF=12.062

30.   Nan Xie,a Ke Feng,b,* Bin Chen,b Ming Zhao,a Shiqi Peng,a,* Li-Ping Zhang,b Chen-Ho Tung,b and Li-Zhu Wub,*,Water-soluble copolymeric materials: the switchable NIR two-photon fluorescence imaging agents for living cancer cells. Journal of Materials Chemistry B, DOI: 10.1039/c0xx00000x    6.101

2012  40.493

31.   Yuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao,* Lin Gui, Ning Li, Li Peng, Xiaoyi Zhang, Li Li and Shiqi Peng*. Novel nano-materials, RGD-tetrapeptide-modified 17b-amino-11a-hydroxyandrost-1,4-diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation. J. Mater. Chem., 2012, 22, 46524659  5.968

32.   Li Li, Ming Zhao,* Wenhao Li, Yuji Wang, Zhuge Zhang, Ran An and Shiqi Peng*. Self-complexation and complexation-controlled target cancer therapy Med. Chem. Commun. 2012, 3, 1059 - 1061   2.8

33.   Gui Lin, Zhao Ming, Wang Yuji, Wang Yinye, Qin Yang, Li Li, Shiqi Peng. Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-α,β-DL-aspartyl-L-arginine. Med. Chem. Commun., 2012, 3, 102-108.   2.8

34.   Jianhui Wu • Lei Wei • Ming Zhao • Yuji Wang Guifeng Kang • Shiqi Peng N-[2(3-Carboxyl-9-benzyl-carboline-1-yl)ethyl-1-yl]-amino acids:correlation of spectral property with in vivo anti-tumor activity, Med Chem Res (2012) 21:116123  1.271

35.   Huiliang Zhang, Yuji Wang,Ming Zhao,* Jianhui Wu, Xiaoyi Zhang, Lin Gui, Meiqing Zheng, Li Li,Jiawang Liu, and Shiqi Peng*. Synthesis and In Vivo Lead Detoxification Evaluation of Poly-α,β-DLaspartyl-L-methionine. Chem. Res. Toxicol. 2012, 25, 471477    3.779

36.   Yuji Wang,a Guifeng Kang,a Jiawang Liu,a Ming Zhao,*a Jianhui Wu, Xiaoyi Zhang,a Ye Li,a Xiaobo Zhong,b Yifan Yanga and Shiqi Peng*a Novel potassium N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxylhex-1-yl]-L-amino acid dichloroplatinates(II) with high anti-tumor activity and low side reaction. Metallomics, 2012, 4, 441447      3.902

37.   Li Li, PhD, Ming Zhao, PhD1, Wenhao Li, MS, Yuji Wang, PhD, Chunna Liu, MS,Zhuge Zhang, BS, Songchun Su, MS, Shiqi Peng, PhD⁎,1 pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy. Nanomedicine: Nanotechnology, Biology, and Medicine xx (2012) xxx–xxx  6.692

38.   Guifeng Kang, Yuji Wang (Co-first author), Jiawang Liu, Jianhui Wu, Ming Zhao, Guochun Li, Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Nathan Mair, Shiqi Peng. Development of three-component conjugates: To get nano-globes with porous surface, high in vivo anti-osteoporosis activity and minimal side effects. J. Mater. Chem., 2012, 22, 21740 - 21748.   5.968

39.   Li Li, Jianhui Wu, Ming Zhao, Yuji Wang, Huiliang Zhang, Xiaoyi Zhang, Lin Gui,  Jiawang Liu, Nathan Mair, and Shiqi Peng, Poly-a,β-DL-Aspartyl-L-Cysteine: A Novel Nano-Material Having Porous Structure, Special Complexation Capability for Pb(II) in vitro and Selectivity of Removing Pb(II) in vivo. Chem. Res. Toxicol., 2012, 25, 1948 - 1954.  3.779

40.   Guodong Yang, Haimei Zhu, Ming Zhao, Jianhui Wu, Yuji Wang, Yanju Wang, Meiqing Zheng, Min Chen, Jiawang Liu, Shiqi Peng, The application of tetrahydroisoquinoline-3- carbonyl-TARGD(F)F as anti-thrombotic agent having dual mechanisms of action. Molecular BioSystems, 2012, 8, 2672-2679.    3.534

41.   Ning Li, Guifeng Kang, Lin Gui, *Ming Zhao, Wenjing Wang, Jianwei Zhang, Yan-Feng Yue, *Shiqi Peng. Novel Cu(II)-RGD-octapeptides: Synthesis, coordination mode, in vitro anti- platelet aggregation/in vivo anti-thrombotic evaluation and correlation of sequence with nano-structure. Nanomed-Nanotechnol. 7, 4, 2011, 403–409   IF=6.692  北医

42.   Liu Liu, Lei Wei, Yifan Yang, Ming Zhao,* Xiaoyi Zhang, Meiqing Zheng, Yuji Wang and Shiqi Peng*, A class of novel AA-Trp-Trp-OBzl: synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and intercalation mechanism. Med. Chem. Commun., 2011, 2, 126-131  2.8

43.   Wenjing Wang, Ming Zhao,* Yuji Wang, Jiawang Liu, Jianhui Wu, Guifeng Kang and Shiqi Peng*{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1Hindol-3-yl}-acetic acid methyl ester (MIAM): Its anti-cancer efficacy andintercalation mechanism identified via multi-model systemsw. Molecular BioSystems. 2011, 7, 766-772   3.534

44.   Hong Wang, Le Peng, Ming Zhao, Jiawang Liu, Xiaoyi Zhang, Yuji Wang,Jianhui Wu, Li Li, Shiqi Peng. 2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquino-lin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation. Bioorganic & Medicinal Chemistry  Volume 19, Issue 2,15 January 2011, Pages 871-882    2.921

45.   Jianhui Wu, Ming Zhao & Shiqi Peng, Quinazolin-4(3H)-ones capable ofupregulating the expression of  endogenous apolipoprotein A-1, Expert Opin. Ther. Patents 2011,21,3 431-435    3.571

46.   Yuji Wang, Xueyun Jiang, Jiawang Liu, Ming Zhao,*Guifeng Kang, Jianhui Wu, Li Peng and Shiqi Peng*,HPLC-MS aided PC12 cell systems: to quantitatively monitor the conversion of nitronyl nitroxide in biological systems with and without NO. Mol. BioSyst., 2011, 7, 16781683     3.534

47.   Yanxia Xu a, Yuji Wang b, Ming Zhao b, Baoguang Hou b, Li Peng b, Meiqing Zheng b, Jianhui Wub, Shiqi Peng. Lead detoxification activities and ADMET hepatotoxicities of a class of novel 5-(1-carbonyl-L-amino-acid)-2,2-dimethyl-[1,3]dithiolane-4-carboxylic acids. Bioorganic & Medicinal Chemistry Letters 21 (2011) 1754–1757  2.554  北医

48.   Yanxia Xu, Yuji Wang, Ling Wang, Ming Zhao,* Xiaoyi Zhang, Xiaomin Hu, Baoguang Hou, Li Peng,Meiqing Zheng, Jianhui Wu, and Shiqi Peng*,Lead Detoxification Activities of a Class of Novel DMSA_Amino Acid Conjugates, Chem. Res. Toxicol. 2011, 24, 979984  3.779

49.   Meiqing Zheng1, Yifan Yang1, Ming Zhao1*, Xiaoyi Zhang1, Jianhui Wu1, Gong Chen2*,Li Peng1, Yuji Wang1 and Shiqi Peng1. A Class of Novel N-Isoquinoline-3-carbonyl-L-amino Acid Benzylesters: Synthesis,Anti-tumor Evaluation and 3D QSAR Analysis. European Journal of Medicinal Chemistry 46 (2011) 1672-1681   3.346

50.   Kun Yao, Ming Zhao*, Xiaoyi Zhang, Yuji Wang, Li Li, Meiqing Zheng, Shiqi Peng**,A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-b-carboline-3-carbonyl]-N0-(amino-acid-acyl) hydrazine: Discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis, European Journal of Medicinal Chemistry 46 (2011) 3237-3249  3.346

51.   Xiaoyi Zhang, Yifan Yang, Ming Zhao**, Liu Liu, Meiqing Zheng, Yuji Wang, Jianhui Wu, Shiqi Peng*,A class of Trp-Trp-AA-OBzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalation-mechanism investigation and 3D QSAR analysis, European Journal of Medicinal Chemistry 46 (2011) 3410-3419   3.346

52.   Yuji Wang,a Lei Wei,a Ming Zhao,*a Shenghui Mei,a Meiqing Zheng,a Yifan Yang,a Hong Wang,a Gong Chen*b and Shiqi Peng*a, Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing micewz, Metallomics, 2011, 3, 1212-1217   3.902

53.   Shenghui Mei,z Jiawang Liu,z Ming Zhao,* Wenjing Wang, Yuji Wang,Guofeng Wu, Meiqing Zheng and Shiqi Peng*From Cerius2 based stereoview to mouse and enzyme: The model systems for discovery of novel urokinase inhibitors, Molecular BioSystems  2011, 7, 26642669    3.534

54.   Yuji Wang, Guifeng Kang, Ming Zhao,* Jianhui Wu,Xiaoyi Zhang, Yifan Yang, Jiawang Liu and Shiqi Peng* A new platinum-complex showing easy preparation, promising anti-tumor activity, and better efficacy anddistribution properties than oxaliplatin. Mol. BioSyst., 2011, 7, 3245-3252   3.534

55.   Jiawang Liu, Yuji Wang, Yifan Yang, Xueyun Jiang, Ming Zhao,* Wenjing Wang, Guofeng Wu, Jianhui Wu, Meiqing Zheng, and Shiqi Peng*[a] Pyrolo[1,2:4,5]-1,4-dioxopyrazino [1,2:1,6]pyrido[3,4-b]indoles: A Group of Urokinase Inhibitors, their Synthesis, and Stereochemistry-Dependent Activity. ChemMedChem. 2011, 6, 12, 23122322 3.306   3.151

56.   Chunyu Li, Xiaoyi Zhang, Ming Zhao**, Yuji Wang, Jianhui Wu, Jiawang Liu, Meiqing Zheng, Shiqi Peng* A class of novel N-(1-methyl-b-carboline-3-carbonyl)-N -(aminoacid-acyl)-hydrazines: Aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. European Journal of Medicinal Chemistry 2011,46, 11, 5598–5608  3.346

57.   Jingcheng Tang, Ming Zhao, Yuji Wang, Guifeng Kang, Jianhui Wu, Meiqing Zheng, Shiqi Peng∗∗.One single HPLC-PDA/(-)ESI-MS/MS analysis to simultaneously determine 30components of the aqueous extract of Rabdosia rubescens  Journal of Chromatography B, 879  (2011) 2783–2793   2.888

58.   Lin Gui, Ming Zhao*,Yinye Wang, Yang Qin, Jiangyuan Liu, Shiqi Peng*. Synthesis, nanofeatures, in vitro thrombus lysis activity and in vivo thrombolytic activity of poly-α, β-aspartyl-L-alanine. Nanomedicine (2010) 5(5), 703714    6.202

59.   Jiawang Liu, Xueyun Jiang,Ming Zhao,* Xiaoyi Zhang, Meiqing Zheng, Li Peng, and Shiqi Peng*. A Class of 3S-2-Aminoacyltetrahydro-β-carboline-3-carboxylic Acids: Their Facile Synthesis, Inhibition for Platelet Activation, and High in Vivo Anti-Thrombotic Potency. J. Med. Chem. 2010, 53, 31063116 (IF=5.207)

60.   Jiawang Liu, Ming Zhao *, Keduo Qian, Xiaoyi Zhang, Kuo-Hsiung Lee*, Jianhui Wu, Yi-Nan Liu, Shiqi Peng,* Benzyl 1,2,3,5,11,11a-hexahydro-3, 3-dimethyl-1-oxo-6H-imidazo [30,40:1,2]pyridin[3, 4-b]indole-2- substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis. Bioorganic & Medicinal Chemistry 18 (2010) 19101917 (IF=2.978)

61.   Xiaoyi Zhang, Wei Wang, Shenling Cheng, Ming Zhao,* Meiqing Zheng, Heng Wei Chang*, Jianhui Wu, Shiqi Peng *. 2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3- carboxylic acids:Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity. Bioorganic & Medicinal Chemistry 18 (2010) 1536–1554  (IF=2.978)

62.   Yinjian Zhou, Ming Zhao*, Yingting Wu, Chunyu Li, Jianhui Wu, Meiqing Zheng, Li Peng, Shiqi Peng ,*. A class of novel Schiff’s bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis. Bioorganic & Medicinal Chemistry 18 (2010) 2165-2172 (IF=2.978)

63.   Ming Zhao, Yuji Wang, Caixia Huo, Jiawang Liu, Chunyu Li, Xiaoyi Zhang, Li Peng, and Shiqi Peng*, Lead Detoxification Activity and ADMET Hepatotoxicity of N-(r-LArabino-furanos-1-yl)-L-cysteine. Chem. Res. Toxicol 2010 237   (4.148)

64.   Jianhui Wu, Chunyu Li, Ming Zhao *, Wenjing Wang, Yuji Wang, Shiqi Peng *, A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis, Bioorganic & Medicinal Chemistry 18 (2010) 6220–6229  2.978

65.   Guifeng Kang, Ming Zhao, Xiaoyi Zhang, Li Peng, Chunbo Li, Wei Mao, Weidong Ye, Shiqi Peng. A class of novel conjugates of substituted purine and Gly-AA-OBzl: Synthesis and evaluation of orally analgesic activity . Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 20, 15 October 2010, Pages 6157-6160  2.661

66.   Fei Huang, Ming Zhao*, Xiaoyi Zhang, Chao Wang, Keduo Qian, Jen-Yun Kuo, Susan Morris- Natschke, Kuo-Hsiung Lee, Shiqi Peng, Synthesis, DNA Intercalation and 3D QSAR Analysis of cis-2,4,5-Trisubstituted-1,3-dithiolanes as a Novel Class of Antitumor Agents. Bioorg. Med. Chem. 2009, 17, 6085–6095    (IF=3.075)

67.   Jianhui Wu, Ming Zhao*, Keduo Qian, Kuo-Hsiung Lee, Susan Morris-Natschke, Shiqi Peng, Novel N-(3-carboxyl-9-benzylcarboline-1-yl)ethylamino acids: Synthesis, antitumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation. Eur. J. Med. Chem. 2009, 44, 4153–4161   (IF=2.882)

68.   Ming Zhao, Jiangyuan Liu, Xiaoyi Zhang, Li Peng, Chunyu Li, Shiqi Peng, 3D QSAR of novel estrogen-RGD peptide conjugates: Getting insight into structural dependence of anti-osteo- porosis activity and side effect of estrogen in ERT. Bioorg. Med. Chem. 2009, 17, 3680-3689.   (IF=3.075)

69.   Ming Zhao, Caixia Huo, Yuji Wang, Chongyu Li, Xiaoyi Zhang, Li Peng, Shiqi Peng, Stereoselective synthesis of Novel N-(α-L-arabinose-1-yl)-L-amino Acids. Tetrahedron: Asymmetry, 2009, 20, 247-258.  (IF=2.796)

70.   Jiangyuan Liu, Xiaoyi Zhang, Ming Zhao*, Shiqi Peng, Synthesis, Evaluation and 3D QSAR Analysis of Novel Estradiol-RGD Octapeptide Conjugates with Oral Anti-osteoporosis Activity, Eur. J. Med. Chem. 2009,44, 1689-1704. (IF=2.882)

71.   Shenling Cheng, Xiaoyi Zhang, Wei Wang, Ming Zhao*, Meiqing Zheng, Heng Wei Chang, Jianghui Wu, Shiqi Peng, A Class of Novel N-(3S-1,2,3,4-Tetrahydroisoquinoline-3- carbonyl)-L-amino Acids: Their Synthesis, Antithrombotic Activity Evaluation and 3D QSAR Analysis. Eur. J. Med. Chem. 442009, 4904-4919 (IF=2.882)

72.   Jinghua Zhao, Guifeng Kang, Wei Wang, Ming Zhao*, Xiaoyi Zhang, Chunbo Lu, Wei Mao, Heng Wei Chang, Weidong Ye, Shiqi Peng, N-[2-Chloro-9H-purin-6-yl]-N-cyclopropyl- glycylamino acids and derivatives: Synthesis, evaluation as a class of novel analgesics and 3D QSAR analysis. Bioorg. Med. Chem. 2009, 17, 6305-6310.   (IF=3.075)

73.   Meiqing Zheng, Xiaoyi Zhang, Ming Zhao*, Heng Wei Chang, Wei Wang, Yuji Wang, Shiqi Peng, (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a Class of Novel Anti-thrombotic Agents: Synthesis, Bioassay, 3D QSAR, and ADME Analysis, Bioorg. Med. Chem. 2008, 16, 9574-9587. (IF=3.075)

74.   Li Li, Guohui Cui, Ming Zhao*, Yuji Wang, Hong Wang, Wei Li, Shiqi Peng, Assembly of β-cyclodextrin with 3S-tetrahydro-β-carboline-3-carboxylic acid and self-assembly of 6-(3S-carboline-3-carboxylaminoethylamino)-6-deoxy-β-cyclodextrin: Approaches to enhance anti-oxidation stability and anti-thrombotic potency. The Journal of Physical Chemistry B, 2008, 112, 12139-12147. (IF=4.189)

75.   Mei Yang, Guohui Cui, Ming Zhao*, Chao Wang, Lili Wang, Hu Liu and Shiqi Peng, The effect of complexation of Cu (II) with P6A peptide and its analogs on their thrombolytic activities, International Journal of Pharmaceutics. 2008, 362, 81-87. (IF=3.061)

76.   Jiawang Liu, Ming Zhao*, Guohui Cui, Xiaoyi Zhang, Jun Wang & Shiqi Peng, Methyl(11as)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indol- 2-substitutedacetates: Synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators, J. Med. Chem. 2008, 51, 4715-4723. (IF=4.898)

77.   Xue Ren, Guohui Cui, Ming Zhao*, Chao Wang, Shiqi Peng, Coordination of Thrombolytic Pro-Ala-Lys peptides with Cu (II): Leading to nano-scale self-assembly, increase of thrombolytic activity and additional vasodilation, The Journal of Physical Chemistry B, 2008, 112, 8174-8180. (IF=4.189)

78.   Yuji Wang, Ming Zhao*, Guohui Cui, Chunying Cui, Jingfang Ju, Shiqi Peng, Therapeutic Alliance: Using N-(2,3,4,5,6-Pentahydroxylhex-1-yl)-N-dithiocarbamate-L-isoleucine Disodium to Improve the Toxicity and Survival of Cisplatin Receiving Mice, The Open Toxicology Journal, 2008, 2, 1-6.

79.   Yu Chen, Guohui Cui, Ming Zhao*, Chao Wang, Keduo Qian, Susan Morris-Natschke, Kuo-Hsiung Lee, Shiqi Peng, Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu, Bioorg. Med. Chem. 2008, 16, 5914-5925. (IF=3.075)

80.   Zhiyu Tang, Ming Zhao*, Changling Li, YinyeWang, Shiqi Peng, Polyaspartoyl·L-arginine inhibits platelet aggregation through stimulation of NO release from endothelial cells, Eur J Pharmacol 2008, 588,41-46. (IF=2.787)

81.   Jianwei Zhang, Ming Zhao*, Guohui Cui, Shiqi Peng, A class of novel nitronyl nitroxide labeling basic and acidic amino acids: Synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigations, Bioorg. Med. Chem. 2008, 16, 4019-4028. (IF=3.075)

82.   Yuwei Wang, Guohui Cui, Ming Zhao*, Jian Yang, Chao Wang, Roger W. Giese, and Shiqi Peng, Bioassay-directed purification of an acidic phospholipase A2 from Agkistrodon Halys Pallas venom, Toxicon 2008, 51, 1331-1339. (IF=2.460)

83.   Xiangmin Li, Ming Zhao*, Yu-Rong Tang, Chao Wang, Ziding Zhang, Shiqi Peng N-[2-(5,5-Dimethyl-1,3-dioxane-2-yl)ethyl]amino acids: Their synthesis, anti-inflammatory evaluation and QSAR analysis, Eur. J. Med. Chem. 2008, 43, 8-18. (IF=2.882)

84.   Lanrong Bi, Ming Zhao*, Keli Gu, Chao Wang, Jingfang Juc, Shiqi Peng, Toward the develop- ment of chemoprevention agents (III): Synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes, Bioorg. Med. Chem. 2008, 16, 1764-1774. (IF=3.075)

85.   Ming Zhao, Zheng Li, Li Peng, Yu-Rong Tang, Chao Wang, Ziding Zhang, Shiqi Peng, A new class of analgesic agents toward prostacyclin receptor inhibition: synthesis, biological studies and QSAR analysis of 1-hydro.xyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines, Eur. J. Med. Chem. 2008, 43, 1048-1058. (IF=2.882)

86.   Ming Zhao, Xin Jia, Chao Wang, Qin Li, Kexiang Zhou, Lili Wang, Hu Liu and Shiqi Peng, PAK: An essential motif for forming β-turn structures and exhibiting thrombolytic effect for P6A and its analogs, Biochem. Cell Biol., 2007, 85, 730-740. (IF=2.473)

87.   Jianghui Wu, Guohui Cui, Ming Zhao*, Chunying Cui, & Shiqi Peng, Novel N-(3-carboxyl-9-benzylcarboline-1-yl)ethylamino acids: Synthesis, anti-proliferation Activities and two step course of intercalation toward calf thymus DNA, Molecular BioSystems, 2007, 3, 855-861. (IF=4.230)

88.   Jiawang Liu, Guohui Cui, Ming Zhao*, Chunying Cui, Jingfang Ju, Shiqi Peng, Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay and SAR of 2,2-dimethyl-3-[1-substi-tutedacetyloxybenzyl]-4- oxoimidazo[3,5:2,3]tetrahydro-β-carbolines, Bioorg. Med. Chem. 2007,15, 7773-7778. (IF=3.075)

89.   Jiawang Liu, Guofeng Wu, Guohui Cui, Wei-Xuan Wang, Ming Zhao*, Chao Wang, Ziding Zhang, Shiqi Peng, A new class of anti-thrombosis hexahydropyrazino[1,2:1,6]- pyrido[3,4-b]indole-1,4-dions: Design, synthesis, logK determination and QSAR analysis, Bioorg. Med. Chem. 2007, 15, 5672-5693. (IF=3.075)

90.   Ming Zhao, Zheng Li, Li Peng, Yu-Rong Tang, Chao Wang, Ziding Zhang, Shiqi Peng, Novel 1-oxyl-2-substitutedphenyl-4,4,5,5-tetramethylimidazolines: Synthesis, selectively analgesic action and QSAR analysis, Bioorg. Med. Chem. 2007, 15, 2815-2826 (IF=3.075)

91.   Keli Gu, Lanrong Bi, Ming Zhao*, Chao Wang, Jingfang Ju, Shiqi Peng, Toward the develo- pment of chemoprevention agents (II): Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes, Bioorg. Med. Chem. 2007, 15, 6273-6290 (IF=3.075)

92.   Yu Xiong, Ming Zhao*, Chao Wang, Hengwei Chang, Shiqi Peng, Improved antiosteoporosis potency and reduced endometrial membrane hyperplasia during HRT with estrogen-RGD peptide conjugates, J Med. Chem. 2007, 50, 3340-3353. (IF=4.898)

93.   Keli Gu, Lanrong Bi, Ming Zhao*, Chao Wang, Jingfang Ju, Shiqi Peng, Toward the development of chemoprevention agents (I): Design, synthesis and anti-inflammatory activities of a new class of 2,5-disubstituted-dioxacycloalkanes, Bioorg. Med. Chem. 2007, 15, 4775-4799 (IF=3.075)

94.   Guofeng Wu, Lanrong Bi, Ming Zhao*, Chao Wang, Michèle Baudy-Floch , Jingfang Ju, Shiqi Peng, Toward breast cancer resistance protein (BCRP) inhibitors: Design, synthesis of a series of new simplified fumitremorgin C analogues, Tetrahedron, 2007, 63, 5510-5528. (IF=2.796)

95.   Yuji Wang, Lanrong Bi, Baoguang Hou, Yu Chen, Ming Zhao*, Chao Wang, Wei Wang, Jingfang Ju,| Shiqi Peng, Design and synthesis of pentahydroxylhexylamino acids and their effect on lead decorporation, Chem. Res. Toxicol. 2007, 20, 609-615. (IF=3.491)

96.   Ming Zhao, Zheng Li, Yihui Wu, Chao Wang, Ziding Zhang, Shiqi Peng, Studies on Log P, retention time and QSAR of 2-substitutedphenylnitronyl nitroxides as free radical scavenger, Eur. J. Med. Chem. 2007, 42, 955-965. (IF=2.882)

97.   Keli Gu, Lanrong Bi, Ming Zhao*, Chao Wang, Cheryl Dolan, Michael C. Kao, Jeffrey B.-H. Tok and Shiqi Peng, Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes, Bioorg. & Med. Chem. 2006, 14,  1339-1347. (IF=3.075)

98.   Ming Zhao, Lanrong Bi, Wei Bi, Chao Wang, Zhe Yang, Jingfang Ju and Shiqi Peng, Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity, Bioorg. & Med. Chem. 2006, 14, 4761-4774. (IF=3.075)

99.   Yihui Wu, Lanrong Bi, Wei Bi, Zeng Li, Ming Zhao*, Chao Wang, Jingfang Ju, Shiqi Peng, Novel 2-substituted nitronyl nitroxides as free radical scavengers: Synthesis, biological evaluation and structureactivity relationship, Bioorg. & Med. Chem. 2006, 14, 5711-5720. (IF=3.075)

100. Ming Zhao, Lanrong Bi, Wei Wang, Chao Wang, Michèle Baudy-Floch, Jingfang Ju, Shiqi Peng, Synthesis and cytotoxic activities of β-carboline amino acid ester conjugates, Bioorg. & Med. Chem. 2006, 14, 6998-7010. (IF=3.075)

101. Ming Zhao, Junling Liu, Chao Wang, Lili Wang, Hu Liu, Shiqi Peng, Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides, J Med. Chem. 2005, 484285-4292. (IF=4.898)

102. Lanrong Bi, Yue Zhang, Ming Zhao*, Chao Wang, Priscilla Chan, Jeffrey B.-H. Tok, Shiqi Peng, Novel synthesis and anti-inflammatory activities of 2,5-disubstituteddioxacycloalkanes, Bioorg. & Med. Chem.  2005, 13, 5640-5646. (IF=3.075)

103. Caixia Huo, Chao Wang, Ming Zhao, Shiqi Peng, Stereoselective synthesis of epimerically pureN-(1-Deoxy-D-fructos-1-yl)-L-amino acids and their effect on lead decorporation , Chem. Res.Toxicol, 2004, 17, 1112-1120  (IF=3.491)

104. Ming Zhao, Chao Wang, Shiqi Peng, The composition and sequence specificity of Pro-Ala-Lys-OH for the throm-bolytic activities of P6A and related oligopeptides, Bioorg. & Med. Chem, 2004, 12, 2275-2286 (IF=3.075)

105. Chao Wang, Ming Zhao, Shiqi Peng, The synthesis and immunosuppressive activities of steroid-urotoxin linkers, Bioorg. & Med. Chem, 2004, 12, 4403-4421 (IF=3.075)

106. Wenfeng Ding, Chao Wang, Ming Zhao, Shiqi Peng, The synthesis, distribution and anti-hepatic cancer activity of YSL, Bioorg. & Med. Chem, 2004, 12, 4989-4994 (IF=3.075)

107. Chao Wang, Ming Zhao,Jian Yang, Xingwei Li, Shiqi Peng, Synthesisi and evaluation of pentahydroxylhexyl-L-cysteine and its dimmer as chelating agents for cadmium or lead decorporation, Toxicology and Applied Pharmacology, 2004, 200, 229-236  (IF=3.364)

108. Ming Zhao, Chao Wang, Yanfen Wu, Kexiang Zhou, and Shiqi Peng, Synthesis and thrombolytic activity of carboline-3-carboxylic acid modified metabolites of ARPAK, Preparative Biochemistry & Biotechnology, 2004, 34, 55-74 (IF=0.683)

109. Chao Wang, Wenfeng Ding, Ming Zhao, Shiqi Peng, Studies on the large scale synthesis and anti-tumor activity of YSL, Preparative Biochemistry & Biotechnology, 2003, 33(3), 189-196   (IF=0.683)

110. Ming Zhao, Na Lin, Chao Wang and Shiqi Peng, Synthesis and thrombolytic activity of fibrinogen fragment related cyclopeptides, Bioorganic & Medicinal Chemistry Letters, 2003, 9, 961-964  (IF=2.531)

111. Y. Qin, X.B. Wang, C. Wang, M. Zhao, M.T. Wu, Y.X. Xu, S.Q. Peng, Application of high-performance liquid chromatography-mass spectrometry to detection of diuretics in human urine, Journal of Chromatography B, 2003, 794, 193-203  (IF=2.50)

112. Chao Wang, Weina Cui, Ming Zhao, Jian Yang and Shiqi Peng, Studies on the synthesis and anti-osteoporosis of estrogen-GHRPS linkers, Bioorganic & Medicinal Chemistry Letters, 2003, 13, 143-146 (IF=2.531)

113. Zhiyu Tang, Yinye Wang, Yanliu Xiao, Ming Zhao, Shiqi Peng, Anti-thrombotic activity of PDR, a newly synthesized L-Arg derivative, on three thrombosis models in rats, Thrombosis Research, 2003, 110, 127-133  (IF=2.449)

114. Ming Zhao, Chao Wang, Jian Yang, Jiangyuan Liu, Youxuan Xu, Yanfen Wu, Shiqi Peng, Identification, synthesis and bioassay for the metabolite of P6A, Bioorganic & Medicinal Chemistry, 2003, 11, 4813-4820  (IF=3.075)

115. Chao Wang, Ming Zhao, Weina Cui, Jian Yang and Shiqi Peng, Studies on the synthesis of estrogen-GHRPS linkers, synthetic communications, 2003, 33(10), 1633-1641 (IF=0.981)

116. Junling Liu, Ming Zhao, Chao Wang, and Shiqi Peng, Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides, Bioorganic & Medicinal Chemistry Letters, 2003,13, 4065-4069 (IF=2.531)

117. Lanrong Bi, Ming Zhao, Chao Wang, Shiqi Peng and Ekkehard Winterfeldt, Diasteroselective cyclizations with enantiopure malonaldehyde monocycloacetals, J. Org. Chem., 2002,67, 22-26 (IF=3.952)

118. Ming Zhao, Chao Wang, and Shiqi Peng, Synthesis of RGD containing peptides and their bioactivitiesPreparative Biochemistry & Biotechnology, 2002, 32 (4), 363-380 (IF=0.683)

119. Yanfen Wu, Ming Zhao, Chao Wang and Shiqi Peng, Synthesis and thrombolytic activity of pseudopeptides related to fibrinogen fragment, Bioorganic & Medicinal Chemistry Letters 2002, 12, 2331-2333  (IF=2.531)

120. Na Lin, Ming Zhao, Chao Wang and Shiqi Peng, Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequende, Bioorganic & Medicinal Chemistry Letters, 2002, 12, 585-587 (IF=2.531)

121. Weina Cui, Chao Wang, Ming Zhao, Shiqi Peng, Effects of synthetic oligopeptides on osteoporosis, Preparative Biochemistry & Biotechnology, 2002, 32(3), 253-268 (IF=0.683)

122. Chao Wang, Ming Zhao, Jian Yang, Shiqi Peng, Synthesis and analgesic effects of kyotorphin-steroid linkers, Steroids, 2001, 66, 811-815 (IF=2.588)

123. Zhao Ming, Wang Chao, Gu Mingdi, Peng ShiQi, Yang Junke, Zhou Kexiang, Wu Saizhu, Studies on the synthesis of Nε-nitro-L-arginine derivatives and their effects on septic shock, Preparative Biochemistry & Biotechnology, 2000, 30(3), 241-246 (IF=0.683)

124. Zhao Ming, Wang Chao, Yang Jian, Peng ShiQi, Synthesis of RGD containing peptides and their vasodilation, Preparative Biochemistry & Biotechnology, 2000, 30(3), 247-256 (IF=0.683)

125. Han Dongmei, Wang Chao, Zhao Ming, Peng ShiQi, Synthesis and analgesic activity of N-(N-acetyl-L-aminoacyl)-5-methoxytryptamines, Preparative Biochemistry & Biotechnology, 2000, 30(1), 39-47 (IF=0.683)

126. Han Dongmei, Wang Chao, Zhao Ming, Peng ShiQi, Synthesis and analgesic activity of N,N-dicarbonyltryptamines, Preparative Biochemistry & Biotechnology, 2000, 30(3), 231-240 (IF=0.683)

127. Lanrong Bi, Ming Zhao, Chao Wang, and Shiqi Peng, E Winterfeldt, Selective Transaceta- lization of 1,1,3,3-tetramethoxypropane and N-benzoylaminodiols, Eur.J.Org.Chem, 2000, 2669-2676 (IF=3.061)

128. Ming Zhao and Shiqi Peng, Studies on hybrid peptides of fragments from fibrinogen. J. Parkt. Chem. 1999, 341 (7), 668-676

129.Ming Zhao, Chao Wang, and Shiqi Peng, Easy generation of an enantiopure general indolalkaloid building block by kinetic resolution, Tetrahedron: Asymmetry 1999, 10, 3899-3905 (IF=2.796)

130. Ming Zhao, Chao Wang, Min Guo, Shiqi. Peng, Ekkehard Winterfeldt Synthesis of 6-amino acid substituted 4,6,7,12-tetrahydro-4-oxoindolo [2,3-a]quinolizines. J. Parkt. Chem. 1999, 341 (7), 692-694

131. Ming Zhao, Chao Wang, Min Guo, and Shiqi Peng, Studies of enantiopure oxoindolo- quinolizines. J. Parkt. Chem. 1999, 341 (7), 677-684

132.JI YongZhao MingQi Ying, Dong Linwang, Wu Liling, Peng Shiqi et al.Effects of Arg-Gly-Asp-Ser on Ca2+ transport of myocardial sarcoplasmic reticulum in rat septic shockActa Pharmacologica Sinica1996, 17(2)129-132  (IF=1.676)

 

 

主编或副主编的著作/译著

1.    Shiqi Peng, Ming Zhao. Pharmaceutical Bioassays. John Wiley. &Sons, Inc, 2009

2.    Shayne Cox Gad, Handbook of Pharmaceutical biotechnology (Chapter 5 Pharmaceutical Bioassays). John Wiley. &Sons, Inc.,2007

3.    彭师奇,《药物化学原理》,北京大学医学出版社,2006

4.    彭师奇,《预防药学》,北京大学医学出版社, 2003

5.    彭师奇,《新药的发现与发明》,山东科学技术出版社,2001

6.    彭师奇,《药物的波普解析》,北京大学医学出版社,1998

7.    彭师奇,《多肽药物化学》,科学出版社,1993

8.    彭师奇,于学敏,《光谱立体化学》,陕西科学技术出版社,1993

9.    彭师奇,赵明,Organic Chemistry,高等教育出版社,2012

10.  赵明,彭师奇,General Chemistry,高等教育出版社,2012

11. 赵明,彭师奇,骨质疏松症及多途径预防策略,高等教育出版社,2013

12. Ming Zhao,Yuji Wang,Jianhui Wu,Shiqi PengTOPICS IN OSTEOPOROSISChapter 4),INTECH2013

13. 彭师奇,赵明,《药物的波谱解析》,高等教育出版社,2014

 

重要奖项

1.北京市科技进步二等奖,2006

2.北京市特聘教授,2006

3.国务院政府津贴,2008

4.首都教育先锋科技创新先进个人,2009

5.北京市教育教学成果二等奖,2009

6.北京市三八红旗奖章荣誉称号,2010

7.北京市教育教学成果二等奖,2013

8.北京市教学名师,2016

 



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