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王玉记

姓名:王玉记

性别:

职称:教授

 

招生院所:药学院

招生类型:硕士

招生专业:药物化学系

研究方向名称:小分子的纳米抗肿瘤药物研究

电子信箱:ccmuwyj@126.comwangyuji@ccmu.edu.cn

个人简介

      1980年出生,博士,教授,首都医科大学化学生物学与药学院副院长。主要从事基于氨基酸的纳米抗肿瘤药物研究,特别是蛋白精氨酸脱亚胺酶4PAD4)抑制剂的研究该文章他引用40次,并且被NIH和宾州州立大学等多家学术网站报道;并根据这样的设计技术,克服临床上阿司匹林药物的缺点,设计并制备了抗血栓小分子纳米药物,被美国化学会的ACS Nano接受,并发表在2013, 7:7664IF=12.0)。基于以上研究,已承担包括863、国家自然科学基金项目、北京市高创计划等十余项项目,已发表SCI期刊论文55篇(IF=195.2),第一作者文章10篇(IF =39.2),作为封面文章1篇,单篇他引次数最高为70次。共申请中国发明专利187项,其中25项授权,包括1项美国专利;专利转化一项(金额100万)。近三年主持项目如下:

1.   2015年科技部863项目,小分子抗肿瘤药物的纳米制备技术研究,117万;

2.   2015年北京市科技转化项目,关于鸟氨酸试剂盒的开发研究,50万;

3.   2015年北京市高创计划项目,小分子纳米抗肿瘤药物研究,50万;

4.   2014年国家自然科学基金面上项目可对接PAD4活性口袋扰乱肿瘤细胞自噬的精氨酸衍生物的构效关系研究,61万;

5.   2013年北京市科技新星项目,新型PAD4抑制剂的合成及抗肿瘤分子机理研究,35万,

教育经历

19988月至20026  北京大学药学院     药学         学士

20028月至20077  北京大学药学院     药物化学 博士

工作经历

20078月至20093 首都医科大学化学生物学院药学院,讲师

20093月至20098 美国宾州州立大学有机化学系,博士后

20098月至20103 美国宾州州立大学生化及分子生物学系,博士后

20103月至201112月首都医科大学化学生物学院药学院 药化系副主任/讲师

20121月至201512月首都医科大学化学生物学院药学院 药化系主任/副教授

20161月至今          首都医科大学药学院 副院长/教授

 

重要学术论文

1.      Yuji Wang, Jingcheng Tang, Haimei Zhu, Xueyun Jiang, Jiawang Liu, Wenyun Xu, Haiping Ma, Qiqi Feng, Jianhui Wu, Ming Zhao, Shiqi Peng. Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis. International Journal of Nanomedicine, 2015, 10:6905-6918.

2.      Guifeng Kang, Yuji Wang (Co-first author), Jiawang Liu, Jianhui Wu, Ming Zhao, Guochun Li, Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Nathan Mair, Shiqi Peng. Development of three-component conjugates: To get nano-globes with porous surface, high in vivo anti-osteoporosis activity and minimal side effects. Journal of Materials Chemistry, 2012, 22:21740-21748. IF=6.63

3.      Yuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao, Lin Gui, Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Shiqi Peng. Novel nano-materials, RGD-tetrapeptide-modified 17b-amino-11a-hydroxyandrost-1,4- diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation. Journal of Materials Chemistry, 2012, 22:4652-4659. IF=6.63

4.      Yuji Wang, Pingxin Li, Shu Wang, Jing Hu, Xiangyun Amy Chen, Jianhui Wu, Megan Fisher, Kira Oshaben, Na Zhao, Ying Gu, Dong Wang, Gong Chen, Yanming Wang. Anticancer PAD inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex activity. Journal of Biological Chemistry, 2012, 287:25941-25953. IF=4.65

5.      Huiliang Zhang, Yuji Wang (Co-first author), Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Lin Gui, Meiqing Zheng, Li Li, Jiawang Liu, Shiqi Peng. Synthesis and In Vivo Lead Detoxification Evaluation of Poly-α,β-DL-aspartyl-L-methionine. Chemical Research in Toxicology, 2012, 25:471-477. IF=4.19

6.      Yuji Wang, Kang Guifeng, Liu Jiawang, Zhao Ming, Wu Jianhui, Zhang Xiaoyi, Li Ye, Zhong Xiaobo, Yang Yifan and Peng Shiqi. Novel potassium N-[(2S,3R,4R,5R)-2,3,4,5,6-Pentahydroxylhex-1-yl]-L-amino acid dichloro- platinates (II) with high anti-tumor activity and low side reaction. Metallomics, 2012, 4:441-447. IF=3.97

7.      Yuji Wang, Xueyun Jiang, Jiawang Liu, Ming Zhao, Guifeng Kang, Jianhui Wu, Li Peng, Shiqi Peng. HPLC-MS aided PC12 cell systems: to quantitatively monitor the conversion of nitronyl nitroxide in biological systems with and without NO. Molecular BioSystems, 2011, 7:1678-1683. IF=3.18

8.      Yuji Wang, Guifeng Kang, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Yifan Yang, Jiawang Liu, Shiqi Peng. A new platinum-complex showing easy preparation, promising anti-tumor activity, and better efficacy and distribution properties than oxaliplatin. Molecular BioSystems, 2011, 7:3245-3252. IF=3.18

9.      Yuji Wang, Lei Wei, Ming Zhao, Shenghui Mei, Meiqing Zheng, Yifan Yang, Hong Wang, Gong Chen, Shiqi Peng. Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice. Metallomics, 2011, 3:1212-1217. IF=3.97

10.   Yuji Wang, Lanrong Bi, Baoguang Hou, Yu Chen, Ming Zhao, Chao Wang, Wei Wang, Jingfang Ju, Shiqi Peng. Design and synthesis of pentahydroxylhexylamino acids and their effect on lead decorporation. Chemical Research in Toxicology, 2007, 20:609-615. IF=4.19

11.   Taiping Gan, Yuji Wang, Ming Zhao, Jianhui Wu, Jian Yang, Shiqi Peng.5-(Bis(3-(2-hydroxyethyl)- 1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHI MHA ): showing a strategy of designing drug to block lung metastasis of tumors.Drug Design, Development and Therapy 2016, 10: 711-721. IF = 3.028

12.   Xi Hu, Ming Zhao, Yuji Wang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Xiangmin Li and Shiqi Peng.Tetrahydro-b-carboline-3-carboxyl-thymopentin: a nano-conjugate for releasing pharmacophores to treat tumor and complications.J. Mater. Chem. B, 2016:4, 1384-1397.     IF=4.726 

13.   Haimei Zhu, Yuanbo Song, Yuji Wang, Ming Zhao, Yi Ren, Yaonan Wang, Shurui Zhao, Jianhui Wu and Shiqi Peng.Design, synthesis and evaluation of a novel π–π stacking nano-intercalator as an anti-tumor agent. Med. Chem. Commun., 2016, 7, 247-257.      IF=2.495

14.   Minna Li, Yuji Wang, Yutong Yang, Yeqing Gao, Ming Zhao, Meiqing Zheng, Shiqi PengOximated ruthenium tris-bipyridyl complex: synthesis and luminescent response specifically for ClO− in water containing multiple ions. Dalton Trans., 2015, 44: 14071-14076.

15.   Feng Wang, Shan Li, Yuji Wang, Haimei Zhu, Xiaoyi Zhang, Ming Zhao, Jianhui Wu, Shiqi Penga, Enantiomeric diketopiperazines: Getting insight of the impact of the configuration to the conformation, nanoimage, u-PA inhibition and anti-metastatic activity. MedChemComm 2015, 6, 956-962.

16.   Fei Gao, Haiqing Liu, Li Li, Jianpeng Guo, Yuji Wang, Ming Zhao, Shiqi Peng. Design, synthesis, and testing of an isoquinoline-3-carboxylic-based novel anti-tumor lead Bioorganic & Medicinal Chemistry Letters, 2015254434-4436.

17.   Hualong Yu, Shenghui Mei, Li Zhao, Ming Zhao, Yuji Wang, Haimei Zhu, Yaonan Wang, Jianhui Wu, Chunying Cui, Wenyun Xu, Shiqi Peng, RGD-peptides modifying dexamethasone: To enhance the efficacy of anti-inflammation and limit the risk of osteoporosis. Med Chem Comm 2015, 6, 1345-1351.

18.   Shan Li, Yuji Wang, Feng Wang, Yaonan Wang, Xiaoyi Zhang, Ming Zhao, Qiqi Feng, Jianhui Wu, Shurui Zhao, Wei Wu, Shiqi Peng, Small molecule PZL318: Forming fluorescent nanoparticles capable of tracing their interactions with cancer cells and activated platelets, slowing tumor growth and inhibiting thrombosis. Int J Nanomed, 2015, 10:5273-5292.

19.   Shan Li, Yuji Wang, Ming Zhao, Jianhui Wu, Shiqi Peng. BPIC: A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals. Bioorg Med Chem Lett. 2015, 25(5):1146-50

20.   Wenhua Zhao, Yuji Wang, Weijia Hao, H Yang, Song X, Ming Zhao, Shiqi Peng. Preparative isolation and purification of urolithins from the intestinal metabolites of pomegranate ellagitannins by high-speed counter-current chromatography.J Chromatogr B Analyt Technol Biomed Life Sci. 2015,990:111-7.

21.   Jianhui Wu, Yuji Wang, Yaonan Wang, Ming Zhao, Xiaoyi Zhang, Lin Gui, Shurui Zhao, Haimei Zhu, Jinghua Zhao, Shiqi Peng. Cu2+-RG DFRG DS: exploring the mechanism and high efficacy of the nanoparticle in antithrombotic therapy.International Journal of Nanomedicine 2015, 10:2925–2938.

22.   Xueyun Jiang, Yuji Wang, Haimei Zhu, Yaonan Wang, Ming Zhao, Shurui Zhao, Jianhui Wu, Shan Li, Shiqi Peng. Modifying tetramethyl–nitrophenyl–imidazoline with amino acids: design, synthesis, and 3D-QSAR for improving inflammatory pain therapy. Drug Design, Development and Therapy 2015, 9: 2329–2342.

23.   Shuangling Chen, Yuji Wang, Shan Li, Yaonan Wang, Ming Zhao, Haimei Zhu, Jianhui Wu, Shiqi Peng. Poly-α,β-aspartyl-Arg-Gly-Asp-Phe: a novel polymeric nanomedicine. Med. Chem. Commun., 2015, 6:182-186.

24.   Wenhua Zhao, Yuji Wang, Weijia Hao, Ming Zhao, Shiqi Peng.In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-β-D-glucose plays a vital role in anti-tumour activity. Biochem Biophys Res Commun. 2014, 445:346-51.

25.   Fengxiang Du, Xiaoyi Zhang, Shan Li, Yaonan Wang, Meiqing Zheng, Yuji Wang, Shurui Zhao, Jianhui Wu, Lin Gui, Ming Zhao and Shiqi Peng. Mechanism of forming trimer, self-assembling nano-particle and inhibiting tumor growth of small molecule CIPPCT. Med. Chem. Commun., 2014,5: 1634-1643.

26.   Haimei Zhu, Yuji Wang, Yaonan Wang, Shurui Zhao, Ming Zhao, Lin Gui, Wenyun Xu, Xiangyun Amy Chen, Yanming Wang, Shiqi Peng.  Folded Conformation, Cyclic Pentamer, Nano-Structure and PAD4 Binding Mode of YW3-56. The Journal of Physical Chemistry C, 2013, 117:10070-10078.

27.   Haimei Zhu, Yuji Wang, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Guodong Yang, Shiqi Peng. Energy minimized crystal structures of P-selectins based on molecular dynamics simulation: leading to two average structures capable of designing anti-thrombotic agents. Med. Chem. Commun., 2013, 4:1066-1072.

28.   Jiawang Liu, Yuji Wang, Yifan Yang, Xueyun Jiang, Ming Zhao, Wenjing Wang, Guofeng Wu, Jianhui Wu, Meiqing Zheng, Shiqi Peng. Pyrolo[1,2:4,5]-1,4-dioxopyrazino [1,2:1,6]pyrido[3,4-b]indoles: A Group of Urokinase Inhibitors, their Synthesis,and Stereochemistry-Dependent Activity. ChemMedChem, 2011, 6: 2312-2322.

29.   Yanxia Xu, Yuji Wang, Ling Wang, Ming Zhao, Xiaoyi Zhang, Xiaomin Hu, Baoguang Hou, Li Peng, Meiqing Zheng, Jianhui Wu, Shiqi Peng. Lead Detoxification Activities of a Class of Novel DMSA-AminoAcid Conjugates. Chemical Research in Toxicology, 2011, 24:979-984.

30.   Yanxia Xu, Yuji Wang, Ming Zhao, Baoguang Hou, Li Peng, Meiqing Zheng, Jianhui Wu, Shiqi Peng. Lead detoxification activities and ADMET hepatotoxicities of a class of novel 5-(1-carbonyl-L-amino-acid)-2,2-dimethyl-[1,3]dithiolane-4-carboxylic acids. Bioorganic Medicinal Chemistry Letters, 2011, 21:1754-1757.  

31.   Yiqing Feng, Yuji Wang, Bradley Landgraf, Shi Liu, Gong Chen. Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp(3) C-H Bonds under Mild Reaction Conditions. Organic Letter, 2010, 12:3414-3417.

32.   Ming Zhao, Yuji Wang, Caixia Huo, Jiawang Liu, Chunyu Li, Xiaoyi Zhang, Li Peng, Shiqi Peng. Lead Detoxification Activity and ADMET Hepatotoxicity of N-(alpha-l-Arabino-furanos-1-yl)-l-cysteine. Chemical Research in Toxicology, 2010, 23:1282-1285. 

33.   Ming Zhao, Yuji Wang, Caixia Huo, Chunyu Li, Xiaoyi Zhang, Li Peng, Shiqi Peng. Stereoselective synthesis of novel N-(a-L-arabinofuranos-1-yl)-L-amino acids. Tetrahedron: Asymmetry, 2009, 20: 20247-20258.

34.   Lin Gui, Ming Zhao, Yuji Wang, Yinye Wang, Yang Qin, Li Li, Shiqi Peng. Synthesis, nano-features, ex vivo anti-platelet aggregation and in vivo antithrombotic activities of poly-α,β-DL-aspartyl-L-arginine. Medicinal Chemistry Communication, 2012, 3:102-108.

35.   Jingcheng Tang, Ming Zhao, Yuji Wang, Guifeng Kang, Jianhui Wu, Meiqing Zheng, Shiqi Peng. One single HPLC-PDA/(-)ESI-MS/MS analysis to simultaneously determine 30components of the aqueous extract of Rabdosia rubescens. Journal of Chromatography B, 2011, 879:2783-2793.

36.   Wenjing Wang, Ming Zhao, Yuji Wang, Jiawang Liu, Jianhui Wu, Guifeng Kang, Shiqi Peng. {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl- ethyl]-1H-indol-3-yl} acetic acid methyl ester (MIAM): its anti-cancer efficacy and intercalation mechanism identified via multi-model systems. Molecular BioSystems, 2011, 7:766-772.

37.   Shaoming Jin, Yaonan Wang, Haimei Zhu, Yuji Wang, Shurui Zhao, Ming Zhao, Jiawang Liu, Jianhui Wu, Wen Gao, Shiqi Peng. Nanosized Aspirin-Arg-Gly-Asp-Val: Delivery of Aspirin to Thrombus by the Target Carrier Arg-Gly-Asp-Val Tetrapeptide. ACS Nano, 2013, 7:7664-7673.

38.   Li Li, Ming Zhao, Wenhao  Li, Yuji Wang, Chunna Liu, Zhuge Zhang, Songchun Su,Shiqi Peng. pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy. Nanomedicine:NBM, 2012, DOI:10.1016/j.nano.2011.12.008

39.   Li Li, Ming Zhao, Wenhao Li, Yuji Wang, Zhuge Zhang, Ran An, Shiqi Peng. Self-complexation and complexation-controlled target cancer therapy. Medicinal Chemistry Communication, 2012, 3:1059-1061.

40.   Li Li, Jianhui Wu, Ming Zhao, Yuji Wang, Huiliang Zhang, Xiaoyi Zhang, Lin Gui, Jiawang Liu, Nathan Mair, Shiqi Peng. Poly-α,β-dl-Aspartyl-l-Cysteine: A Novel Nanomaterial Having a Porous Structure, Special Complexation Capability for Pb(II), and Selectivity of Removing Pb(II). Chemical Research in Toxicology,2012, 25:1948-1954

41.   Chunyu Li, Xiaoyi Zhang, Ming Zhao, Yuji Wang, Jianhui Wu, Jiawang Liu, Meiqing Zheng, Shiqi Peng. A class of novel N-(1-methyl-b-carboline-3-carbonyl)-N’ -(aminoacid-acyl)- hydrazines: Aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. European Bioorganic Medicinal Chemistry, 2011, 46:5598-5608.

42.   Jianhui Wu, Lei Wei, Ming Zhao, Yuji Wang, Guifeng Kang, Shiqi Peng. N-[2(3-Carboxyl-9-benzyl-carboline-1-yl)ethyl-1-yl]-amino acids: correlation of spectral property with in vivo anti-tumor activity. Medicinal Chemistry Research, 2010, DOI:10.1007/s00044-010-9504-1

43.   Li Li, Guohui Cui, Ming Zhao, Yuji Wang, Hong Wang, Wei Li, Shiqi Peng . Assembly of beta-cyclodextrin with 3S-tetrahydro-beta-carboline-3-carboxylic acid and self-assembly of 6-(3'S-carboline-3'-carboxylaminoethylamino)-6-deoxy-β-cyclodextrin. Journal of Physical Chemistry B, 2008, 112:12139-12147.

44.   Kun Yao, Ming Zhao, Xiaoyi Zhang, Yuji Wang, Li Li, Meiqing Zheng, Shiqi Peng. A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-b-carboline-3-carbonyl]-N-(amino-acid-acyl)hydrazine: Discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. European Journal of Medicinal Chemistry, 2011, 46:3237-3249.

45.   Guodong Yang, Haimei Zhu, Ming Zhao, Jianhui Wu, Yuji Wang, Yanju Wang, Meiqing Zheng, Min Chen, Jiawang Liu, Shiqi Peng. The application of tetrahydroisoquinoline-3-carbonyl-TARGD(F) F as an anti-thrombotic agent having dual mechanisms of action. Molecular BioSystems, 2012, 8:2672-2679.

46.   Shenghui Mei, Jiawang Liu, Ming Zhao, Wenjing  Wang, Yuji Wang, Guofeng Wu, Meiqing Zheng, Shiqi Peng. From Cerius2 based stereoview to mouse and enzyme: the model systems for discovery of novel urokinase inhibitors. Molecular BioSystems, 2011, 7:2664-2669.

47.   Jianhui Wu , Chunyu Li, Ming Zhao, Wenjing Wang, Yuji Wang, Shiqi Peng. A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis. Bioorganic & Medicinal Chemistry, 2010, 18: 6220-6229.

48.   Hong Wang, Le Peng, Ming Zhao, Jiawang Liu, Xiaoyi Zhang, Yuji Wang, Jianhui Wu, Li Li, Shiqi Peng. 2-Substituted (S)-2-(3,3-dimethyl-1-oxo- 10,10a-dihydroimidazo[1,5-b] isoquinolin-2(1H,3H,5H)-yl) acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation. Bioorganic & Medicinal Chemistry, 2011, 19:871-882.

49.   Xiaoyi Zhang, Yifan Yang, Ming Zhao, Liu Liu, Meiqing Zheng, Yuji Wang, Jianhui Wu, Shiqi Peng. A class of Trp-Trp-AA-OBzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalation-mechanism investigation and 3D QSAR analysis, European Bioorganic Medicinal Chemistry, 2011, 46:3410-3419.

50.   Meiqing Zheng, Xiaoyi Zhang, Ming Zhao, Heng Wei Chang, Wei Wang, Yuji Wang, Shiqi Peng. (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis. Bioorganic Medicinal Chemistry, 2008, 16:9574-9587.

51.   Jiawang Liu,Shannon Taylor, Patrick Dupart, Corey Arnold, Jayalakshmi Sridhar, Quan Jiang, Yuji Wang, Elena Skripnikova, Ming Zhao, Maryam Foroozesh. Pyranoflavones: A Group of Small-molecule Probes for Exploring the Active Site Cavities of Cytochrome P450 Enzymes 1A1, 1A2, and 1B1. Journal of Medicinal Chemistry, 2013, 56(10):4082-4092.

52.   Liu Liu, Lei Wei, Yifan Yang, MingZhao, Xiaoyi Zhang, Meiqing Zheng, Yuji Wang, Shiqi Peng. A class of novel AA-Trp-Trp-OBzl: synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and intercalation mechanism. Medicinal Chemistry Communication, 2011, 2:126-131.

53.   Meiqing Zheng, Yifan Yang, Xiaoyi Zhang, Ming Zhao, Jianhui Wu, Gong Chen, Li Peng, Yuji Wang, Peng Shiqi. A class of novel N-isoquinoline-3-carbonyl-l-amino acid benzyl esters: Synthesis, anti-tumor evaluation and 3D QSAR analysis. European Bioorganic Medicinal Chemistry, 2011, 46:1672-1681.

54.   Adharsh P. Ponnapakam, Jiawang Liu, Kaustubh N. Bhinge, Barbara A. Drew, Tony L. Wang, James W. Antoon, Thong T. Nguyen, Patrick S. Dupart, Yuji Wang, Ming Zhao, Yong-Yu Liu, Maryam Foroozesh , Barbara S. Beckmana. 3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells. Bioorganic & Medicinal Chemistry, 2014 , 22:1412-1420.

55.   Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Yuji Wang, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. A Ligand-Based Drug Design, Discovery of 4-Trifluoromethyl-7,8-Pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.J Med Chem. 2015, 58(16):6481-6493

重要奖项

1. 2015年北京市高创计划青年拔尖人才

2. 2014年霍英东青年教师奖

3. 2011年北京市教育先锋号(排名2



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