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叶玲

  Tel:010-83951525

  E-mail:lingye@ccmu.edu.cn

  招生类别:博士(科学学位)、硕士(科学学位)

  个人简历

  1998年10月~至今:首都医科大学,讲师,副教授,教授

  1995年9月~1999年3月:北京理工大学化学化工与材料学院材料学博士

  1992年9月~1995年2月:北京理工大学化学化工与材料学院应用化学硕士

  1982年9月~1986年7月:中北大学化工学院精细化工学士

  社会兼职

  1.教育部大学化学教学指导委员会委员

  研究方向

  1.纳米材料与靶向药物递送

  2.造影剂用于脑胶质瘤成像的研究

  3.光学材料用于术中导航的研究

  课题情况(主持)课题名称、类型、资助时间、资助金额

  1.双靶双模态分子探针增强脑胶质瘤特异性成像的研究(81271639),国家自然科学基金,2013.1-2016.12,70万元

  代表文章:

  1.Penghui Ai, Hao Wang, Kang Liu, Tingjian Wang, Wei Gu, Ling Ye* and Changxiang Yan*. The relative length of dual-target conjugated oniron oxide nanoparticles plays a role in brain gliomatargeting.RSC Adv.,2017, 7, 19954-19959

  2.Kang Liu, Xin Shi, Tingjian Wang, Penghui Ai, Wei Gu*, and Ling Ye*, Terbium-doped Manganese Carbonate Nanoparticles with Intrinsic Photoluminescence and Magnetic Resonance Imaging Capacity, Journal of Colloid and Interface Science, 2017, 485: 25-31.

  3.Xin Shi, Kang Liu, Tingjian Wang, Shunjia Zheng, Wei Gu*, and Ling Ye*, Formation Mechanism of Dysprosium-doped Manganese Carbonate Nanoparticles by Thermal Decomposition, RSC Advance, 2016, 6(101): 99339-99345.

  4.Juan Zhang#, Ning Chen#, Hao Wang, Wei Gu, Kang Liu, Penghui Ai, Changxiang Yan*, and Ling Ye*, Dual-targeting Superparamagnetic Iron Oxide Nanoprobes with High and Low Target Density for Brain Glioma Imaging Journal of Colloid and Interface Science, 2016, 469: 86-92.

  5.Chen Shao#, Shuai Li#, Wei Gu, Ningqiang Gong, Juan Zhang, Ning Chen, Xiangyang Shi* and Ling Ye*, Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas, Analytical. Chemistry, 2015, 87, 6251-6257.

  6.Shuai Li#, Chen Shao#, Wei Gu, Rui Wang, Juan Zhang, Junxin Lai, Hansheng Li* and Ling Ye*, RSC Advance, 2015, 5, 33639-33645.

  7.Ning Chen#, Chen Shao#, Shuai Li, Zihao Wang, Yanming Qu, Wei Gu*, Chunjiang Yu* and Ling Ye*, Cy5.5 Conjugated MnO Nanoparticles for Magnetic Resonance/Near-infrared Fluorescence Imaging of Brain Gliomas, Journal of Colloid and Interface Science., 2015, 457, 27-34.

  8.Ning Chen, Chen Shao, Yanming Qu, Shuai Li, Wei Gu*, Tingting Zheng, Ling Ye*, and Chunjiang Yu*, Folic Acid-Conjugated MnO Nanoparticles as a T1 Contrast Agent for Magnetic Resonance Imaging of Tiny Brain Gliomas, ACS Applied Materials & Interfaces,2014, 6(22): 19850-19857.

  9.Ning Xiao, Wei Gu, Hao Wang, Yunlong Deng, Xin Shi, and Ling Ye*, T1-T2 Dual-modal MRI of Brain Gliomas using PEGylated Gd-doped Iron Oxide

  Nanoparticles, Journal of Colloid and Interface Science, 2014, 417: 159-165.

  10.Yunlong Deng#, Hao Wang#, Wei Gu, Shuai Li, Ning Xiao, Chen Shao, Qunyuan Xu*, and Ling Ye*, Ho3+ Doped NaGdF4 Nanoparticles as MRI/optical Probes for Brain Glioma Imaging, Journal of Materials Chemistry B, 2014, 2(11): 1521-1529.

  11.Wei Gu#, Guangrong Song#, Shuai Li, Chen Shao, Changxiang Yan*, and Ling Ye*, Chlorotoxin-conjugated, PEGylated Gd2O3 Nanoparticles as a Glioma-specific Magnetic Resonance Imaging Contrast Agent, RSC Advances, 2014, 4(91): 50254-50260.

  12.Fuying Li, Wei Gu, Hao Wang, Yingzhe Qi, Yunlong Deng, Ning Xiao, Yi Liu, Qunyuan Xu*, and Ling Ye*, Effect of Surface Functionalities on Relaxometric Properties of MR Contrast Agents Based on NaGdF4 Nanoparticles, RSC Advances, 2013, 3(16): 5386-5392.

  13.Yingzhe Qi, Chen Shao, Wei Gu, Fuying Li, Yunlong Deng, Hansheng Li*, and Ling Ye*, Carboxylic Silane-exchanged Manganese Ferrite Nanoclusters with High Relaxivity for Magnetic Resonance Imaging, Journal of Materials Chemistry B, 2013, 1(13): 1846-1851.

  14.Feng Yan#, Ying Wang#, Shenzhi He, Shuting Ku, Wei Gu*, and Ling Ye*, Transferrin-conjugated, Fluorescein-loaded Magnetic Nanoparticles for Targeted Delivery across the Blood-brain Barrier, Journal of Materials Science: Materials in Medicine, 2013, 24(10): 2371-2379.

  15.Xixuan Li, Jianqun Shao, Ying Qin, Chen Shao, Tingting Zheng, and Ling Ye*, TAT-conjugated nanodiamond for the enhanced delivery of doxorubicin, Journal of Materials Chemistry, 2011, 21(22): 7966-7973.

  16.Ying Qin, Liang Sun, Xixuan Li, Qingqing Cao, Hao Wang, Xingfu Tang*, and Ling Ye*, Highly Water-dispersible TiO2 Nanoparticles for Doxorubicin Delivery: Effect of Loading Mode on Therapeutic Efficacy, Journal of Materials Chemistry, 2011, 21(44): 18003-18010.

  17.Liang Sun, Ying Qin, Qingqing Cao, Bingqing Hu, Zhiwei Huang, Ling Ye*, and Xingfu Tang*, Novel Photocatalytic Antibacterial Activity of TiO2 Microspheres Exposing 100% Reactive {111} Facets, Chemical Communications, 2011, 47(47): 12628-12630.

  18.Shanshan Huang, Jianqun Shao, Lifang Gao, Yingzhe Qi, and Ling Ye*, Adsorption of Cathepsin B-sensitive Peptide Conjugated DOX on Nanodiamonds, Applied Surface Science, 2011, 257(20): 8617-8622.

  19.Shuting Ku, Feng Yan, Ying Wang, Yilin Sun, Nan Yang, and Ling Ye*, The Blood-brain Barrier Penetration and Distribution of PEGylated Fluorescein-doped Magnetic Silica Nanoparticles in Rat Brain, Biochemical and Biophysical Research Communications, 2010, 394(4): 871-876.   

  20.Ying Qin#, Yixuan Zhang#, Shulian Yan, and Ling Ye*, A Comparison Study on the Interaction of Hyperoside and Bovine Serum Albumin with Tachiya Model and Stern-Volmer Equation, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2010, 75(5): 1506-1510.

  21.Xixuan Li#, Shulian Yan#, Yixuan Zhang, and Ling Ye*, Study on the Interaction of Raloxifene and Bovine Serum Albumin by the Tachiya Model, Journal of Solution Chemistry, 2010, 39(8): 1187-1199.

  22.Jingxian Yu, Huanying Zhao, Ling Ye*, Hui Yang, Shuting Ku, Nan Yang, Ning Xiao. Effect of surface functionality of magnetic silica nanoparticles on the cellular uptake by glioma cells in vitro. Journal of Materials Chemistry, 2009, 19(9): 1265-1270.

  23.Nan Wang, Ling Ye*, Bingqing Zhao, Jingxian Yu. Spectroscopic studies on the interaction of efonidipine with bovine serum albumin. Brazilian Journal of Medical and Biological Research, 2008, 41(7): 589-595.

  24.Nan Wang, Ling Ye*, Fangfei Yan, Ren Xu. Spectroscopic studies on the interaction of azelnidipine with bovine serum albumin. International Journal of Pharmaceutics, 2008, 351(1-2): 55-60.

  25.Congxia Wang, Fangfei Yan, Yixuan Zhang, Ling Ye*. Spectroscopic investigation of the interaction between rifabutin and bovine serum albumin. Journal of Photochemistry and Photobiology A: Chemistry, 2007, 192(1): 23-28.

 

发明专利:

   1.叶玲,于景娴,王楠,赵焕英,杨慧,高琳. 一种硅壳荧光磁性纳米粒及制备方法和应用,20121219日授权,中国专利,专利号:ZL 200810119801.4

 

出版教材:

  1.有机化学, 第8版,副主编,人民卫生出版社(ISBN978-7-117-10105-9),卫生部规划教材,2013

  2.有机化学, 第3版,参编,人民卫生出版社(ISBN978-7-117-17320-9),全国高等学校医药学成人学历教育专科规划教材,2013

  3.Organic Chemistry, 参编,高教出版社(ISBN 978-7-04-034811-8),2012

  4.有机化学, 第7版,参编,人民卫生出版社(ISBN 978-7-117-10066-3),国家级规划教材,2008

  5.医用基础化学,第3版,参编,北京大学医学出版社(ISBN 978-7-81116-521-0),普通高等教育“十一五“国家级规划教材”,2008

  6.有机化学, 第2版,参编,高教出版社(ISBN 978-7-04-028026-5),2009

  7.有机化学, 第2版,参编,人民卫生出版社(ISBN 978-7-117-091145),全国高等学校医药学成人学历教育专科规划教材,2007

   8.有机化学习题解析,第1版,主编,高等教育出版社(ISBN 7-04-015581-8),2004

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