2020 Guanyu Li, Tong Wang, Xiaoyi Zhang, Shurui Zhao, Yaonan Wang, Jianhui Wu, Shiqi Peng*，Ming Zhao*. Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation. Drug Design, Development and Therapy.2020:14 2187–2197. Mengyu Hou, Manjie Lv, Xiaoyi Zhang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Ming Zhao*, Shiqi peng*. Discovery of novel 6S/12aS-heptachpyridone capable of targeting thrombus and inhibiting thrombosis in vivo. Journal: Bioorganic & Medicinal Chemistry Letters. Volume 30, Issue 19, 1 October 2020, 127440 Xiaoyi Zhang,Yixin Zhang,Yaonan Wang,Jianhui Wu,Haiyan Chen,Ming Zhao*,Shiqi Peng*. Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form Nano-Medicine. International journal of nanomedicine, (2020): 465-481 Xiaoyi Zhang1,2, Jinhuan Zhang1,2, Wenchao Liu1,2, Yaonan Wang1,2, Jianhui Wu1,2, Shurui Zhao1,2, Ming Zhao1,2,3* & Shiqi Peng1,2*。Exploring the action of RGDV‑gemcitabine on tumor metastasis, tumor growth and possible action pathway. Scientific Reports | (2020) 10:15729
2019 Guanyu Li, Yi Ren, Xiaoyi Zhang, Shurui Zhao, Yaonan Wang, Jianhui Wu, Shiqi Peng*, Ming Zhao*. 13-[CH2CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein. Onco Targets Ther 2019 Dec 5;12:10651-10662 Wenchao Liu1,2 Yujia Mao1,2 Xiaoyi Zhang1,2 Yaonan Wang1,2 Jianhui Wu 1,2 Shurui Zhao1,2 Shiqi Peng 1,2 Ming Zhao*1.RGDV-modified gemcitabine: a nano-medicine capable of prolonging half-life, overcoming resistance and eliminating bone marrow toxicity of gemcitabine. International Journal of Nanomedicine 2019:14 7263–7279 Shurui Zhao，Ze Li，Fei Huang，Jianhui Wu，Lin Gui，Xiaoyi Zhang，Yaonan Wang，Xiaozhen Wang，Shiqi Peng，Ming Zhao*. Nano-scaled MTCA-KKV: for targeting thrombus,releasing pharmacophores, inhibiting thrombosisand dissolving blood clots in vivo. International Journal of Nanomedicine 2019:14 4817–4831 Jianhui Wu,Yue Cui,Xiaoyi Zhang,Lin Gui,Yaonan Wang,Shiqi Peng,Ming Zhao,*. BCESA: a nano-scaled intercalator capable of targeting tumor tissue and releasing antitumoral β-carboline-3-carboxylic acid. International Journal of Nanomedicine 2019:14 3027–3041 Juan Feng, Meng Zhou, Xuanzi Lin, An Lu, Xiaoyi Zhang, and Ming Zhao*.Base-Mediated [3 + 4]-Cycloaddition of Anthranils with Azaoxyallyl Cations: A New Approach to Multisubstituted Benzodiazepines. Org. Lett. 2019, 21, 6245−6248. Shuangling Chen , Zidong Peng, Yuji Wang , Jianhui Wu, Ran An , Rongrong Miao , Ming Zhao , * , Shiqi Peng ，Development and activity evaluation of Arg-Gly-Asp-containing antithrombotic conjugate，Journal of Molecular Structure 1198 (2019) 126816
2018 Yaonan Wang, Haiyan Chen, Xiaoyi Zhang, Jianhui Wu,Qiqi Feng, Shiqi Peng,, Ming Zhao.* Dimethyl 2,2′-[2,2′-(ethane-1,1-diyl)bis(1H-indole-3,2-diyl)]-diacetate: a small molecule capable of nano-scale assembly, inhibiting venous thrombosis and inducing no bleeding side effect. International Journal of Nanomedicine 2018:13 7835–7844 Jianhui Wu, a§ Haimei Zhu, a§ Guodong Yang,a Jianhong He, *c Yuji Wang, a Shurui Zhao,a Xiaoyi Zhang,a Lin Gui,a Ming Zhao*a,b & Shiqi Peng*a, Design and synthesis of nano-scaled IQCA-TAVV as a delivery capable of anti- platelet activation, targeting arterial thrombus and releasing IQCA. International Journal of nanomedicine 2018 , 13 :1139-1158 Ze Li, Fei Huang, Jianhui Wu, Lin Gui, Xiaoyi Zhang, Yaonan Wang, Shurui Zhao, Xiaozhen Wang, Shiqi Peng*, and Ming Zhao*. Heptapeptide based modification leading to enhancing the action of MTCA on activated platelets, P-selectin, GPIIb/IIIa. Future Medicinal Chemistry. 2018 , 10 (16) :1957-1970 Haiyan Chen, An Lu, Xiaoyi Zhang, Lin Gui, Yaonan Wang, Jianhui Wu, Hua Feng, Shiqi Peng* and Ming Zhao* .Design and development of ICCA as dual inhibitor of GPIIb/IIIa and P-selectin receptors.Drug Design, Development and Therapy. 2018; 12: 2097–2110. Haimei Zhu, Yuji Wang, Ce Song, Qiqi Feng, Jianhui Wu, Shurui Zhao, Lin Gui, Xiaoyi Zhang, Ming Zhao and Shiqi Peng. Docking of THPDTPI: to explore P-selectin been a common target of anti-tumor, anti-thrombotic and anti-inflammatory agent,\. Oncotarget, 2018 , 9 (1) :268-281 Haiyan Chen，Wenjing Wang，Xiaoyi Zhang，Shan Liu，Yaonan Wang，Haimei Zhu，Jianhui Wu，Yuji Wang，Ming Zhao (*) ， Shiqi Peng (*), Discovery of DEBIC to correlate P-selectin inhibition and DNA intercalation incancer therapy and complicated thrombosis，Oncotarget，2018,9(63),32119-32133
2017 Jianhui Wu, a§ Haimei Zhu, a§ Guodong Yang,a Yuji Wang, a Yaonan Wang, a Shurui Zhao,a Ming Zhao*a,b & Shiqi Peng*a, IQCA-TAVV: To get insight of the association between P-selectin, GPIIb/IIIa, IL-2, IL-6 and IL-8 into deep venous thrombosis. Oncotarget, 2017 , 8 (53) :91391-91401 Jianhui Wu# , Haimei Zhu#, Ming Zhao, Yuji Wang ,Guodong Yang, Yaonan Wang, Shurui Zhao,Lin Gui,Xiaoyi Zhang,and Shiqi Peng. IQCA-TASS: A nano-scaled P-selectin inhibitor capable of targeting thrombus and releasing IQCA/TARGD(S)S in vivo， J. Mater. Chem. B, 2017, 5, 917—927 Jianhui Wu, Ming Zhao, Yuji Wang, Yaonan Wang, Haimei Zhu, Shurui Zhao, Lin Gui, Xiaoyi Zhang, and Shiqi Peng*, N-(3-hydroxymethyl-β-carboline-1-yl-ethyl-2-yl)-l-Phe:development toward nanoscaled antitumor drug capable of treating complicated thrombosis and inflammation, Drug design, development and therapy , 2017 , 11 :225-239 Haiping Ma, Ming Zhao, Yuji Wang, Haimei Zhu, Yaonan Wang, Shurui Zhao, Jianhui Wu, Shiqi Peng Cholyl-L-Lysine-carboxyl butyryl adriamycin produgs targeting chemically induced liver injury. J. Mater. Chem. B , 2017,5, 470-478 Xinyi Xu, Yuji Wang, Jianhui Wu, Xi Hu, Haimei Zhu, Xiaoyi Zhang, Yaonan Wang, Lin Gui, Ming Zhao, Shiqi Peng. ATIQCTPC: a nanomedicine capable of targeting tumor and blocking thrombosis in vivo. International Journal of Nanomedicine, 2017, 12: 4415 -4431 Yuji Wang, Xinyi Xu, Ce Song, Jianhui Wu, Xi Hu, Haimei Zhu, Xiaoyi Zhang,Yaonan Wang, Lin Gui, Ming Zhao, and Shiqi Peng. ATIQCTPC targeting MMP-9: a key step to slowing primary tumor growth and inhibiting metastasis of lewis lung carcinoma in vivo. Oncotarget, 2017, 8, 38, 63881-63889 Haimei Zhu, Yuji Wang, Ce Song, Qiqi Feng, Jianhui Wu, Shurui Zhao, Lin Gui, Xiaoyi Zhang, Ming Zhao and Shiqi Peng. Docking of THPDTPI: to explore P-selectin been a common target of anti-tumor, anti-thrombotic and anti-inflammatory agent,\. Oncotarget, 2018 , 9 (1) :268 Xiaozhen Wang , Yuji Wanga, Jianhui Wu, Lin Gui , Xiaoyi Zhang , Meiqing Zheng , Yaonan Wang, Shurui Zhao , Ze Li , Ming Zhao*, Shiqi Peng* .Docking based design of diastereoisomeric MTCA as GPIIb/IIIa receptor inhibitor.Bioorganic & Medicinal Chemistry Letters 27 (2017) 5114–5118 Haiyan Chen，Wenjing Wang，Xiaoyi Zhang，Shan Liu，Yaonan Wang，Haimei Zhu，Jianhui Wu，YujiWang，Ming Zhao (*) ， Shiqi Peng (*), Discovery of DEBIC to correlate P-selectin inhibition and DNA intercalation incancer therapy and complicated thrombosis，Oncotarget
2016 Taiping Gan, Yuji Wang, Ming Zhao, Jianhui Wu, Jian Yang, Shiqi Peng.,5-(Bis(3-(2-hydroxyethyl)- 1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHI MHA ): showing a strategy of designing drug to block lung metastasis of tumors.Drug Design, Development and Therapy 2016, 10: 711-721. Xi Hu, Ming Zhao, Yuji Wang, Yaonan Wang, Shurui Zhao, Jianhui Wu, Xiangmin Li and Shiqi Peng ,Tetrahydro-b-carboline-3-carboxyl-thymopentin: a nano-conjugate for releasing pharmacophores to treat tumor and complications. J. Mater. Chem. B, 2016:4, 1384-1397. Xu Wenyun, Zhao Ming, Wang Yuji, Zhu haimei, Wang Yaonan, Zhao Shurui, Wu Jianhui, Peng Shiqi ,Design, synthesis, and in vivo evaluations of benzyl Nω-nitro-Nα-(9H-pyrido[3,4-b]indole-3-carbonyl)-L-argininate as an apoptosis inducer capable of decreasing the serum concentration of P-selectin. Medchemcomm, 2016, 7, 1730 Ning Song,Ming Zhao,Yuji Wang,Xi Hu,Jianhui Wu,Xueyun Jiang,Shan Li,Chunying Cui,Shiqi Peng1 Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of s180 mice treated with mtx/mit.. Drug Design Development & Therapy,2016， Volume 10, 2701-2711. Qiqi Feng, Ming Zhao*,Taiping Gan, Haimei Zhu, Yaonan Wang, Shurui Zhao, Yuji Wang, Jianhui Wu and Shiqi Peng*.DHDMIQK(KAP): a novel nano-delivery system of dihydroxyl-tetrahydro-isoquinoline-3-carboxylic acid and KPAK towards the thrombus. Journal of Materials Chemistry B. 2016. 4. 5991-6003. Lv Xiaojie, Zhao Ming*, Wang Yuji, Hu Xi, Wu Jianhui, Jiang Xueyue, Li Shan, Cui Chunying, Peng Shiqi*.Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy. Drug Design, Development and Therapy. 2016. 10. 3933-3946. Zhigang Zhao, Xingang Li, Shusen Sun,Shenghui Mei,Ning Ma,Zhongrong Miao,Ming Zhao* , Shiqi Peng*. Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis. European Journal of Clinical Pharmacology. 2016. 72（10）. 1195-1204. Jianhui Wu, Ming Zhao, Yuji Wang, Yaonan Wang, Haimei Zhu, Shurui Zhao, Shiqi Peng, A novel lead of P-selectin inhibitor: Discovery, synthesis, bioassays and action mechanism. Bioorg Med Chem Lett, 2016, 26, 4631 - 4636 Haimei Zhu, Yuanbo Song, Yuji Wang, Ming Zhao, Yi Ren, Yaonan Wang, Shurui Zhao, Jianhui Wu and Shiqi Peng .Design, synthesis and evaluation of a novel π–π stacking nano-intercalator as an anti-tumor agent MedChemComm. 2016, 7, 247-257 xueyun jiang，ming zhao，haimei zhu，shurui zhao，yuanbo song，shiqi，peng .RGD(F/S/V)-Dex: towards the development of novel, effective, and safe glucocorticoids Drug Design, Development and Therapy2016:10 1059-1076 Yinghuan Li, Lei Gao, Xi Tan, Feiyang Li, Ming Zhao, Shiqi Peng .Lipid rafts-mediated endocytosis and physiology-based cell membrane traffic models of doxorubicin liposomes .Biochimica Biophysica Acta 2016, 1858 (8) : 1801–1811 |
