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崔纯莹

姓名:崔纯莹

性别:女

职称:教授

招生院所:药剂学系

招生类型:硕士

招生专业:药剂学

研究方向名称:基因药学

电子信箱:ccy@ccmu.edu.cn

个人简介

    开展新型载体材料研究,包括靶向制剂、缓控释制剂和基因载体系统的研究工作。利用多种模拟模型和新技术加强通过细胞和分子层次的结构与功能研究,由体内反馈情报指导靶向于细胞水平的给药系统的设计,以更为稳定、有效地实现体内输送。以抗肿瘤药物和基因片段作为研究对象,应用肿瘤细胞模型和生物物理技术为研究手段,通过载体结构及其组分对药物经细胞膜扩散的影响、对细胞内基因的表达、蛋白表达的变化规律为指标,在稳定性和跨膜转运机理等研究基础上进行载体系统设计和制备。建立研究跨膜机制,吸收机制、细胞模型、表达谱测定模型、药物体外释放与体内吸收相关性研究平台。作为学术骨干曾参与北京市教委科研基地-药物基因组学科技创新平台建设项目。作为项目负责人已完成北京市教委面上项目(2008年),北京市中青年骨干教师项目(2009年),北京市优秀人才资助(2009年),首都医科大学基础-临床重点课题(2011年),首都医科大学基础-临床面上课题(2010年),中国第55批博士后科学基金面上资助(2013年),北京市属高等学校高层次人才引进与培养-青年拔尖人才培育项目(2013-2015)。现负责承担国家自然科学基金面上青年项目1项(2016-2018),首都医科大学基础临床面上乙方项目1项(2016-2018),首都医科大学校长基金项目1项(2016-2017)。申请国家发明专利4项,其中作为第1发明人1项。国外SCI论文15篇,其中第一或责任作者9篇,发表国内刊物论文14篇。

 

教育经历

19959-19998 北京医科大学药学院 学士学位

20019-20068 北京大学药学院 博士学位

20043-20064 新加坡国立大学附属医院 血液肿瘤科联培博士

20137-20157 首都医科大学药学院 博士后

 

工作经历

19999-20018 北京大学医学部

20068 至今 首都医科大学药学院

 

重要学术论文

1.Yanzhao Bi, Yifan Zhang, Chunying Cui*, Lulu Ren, Xueyun Jiang. Gene-silencing effects of anti-survivin siRNA delivered by RGDV-functionalized nanodiamond carrier in the breast carcinoma cell line MCF-7. Int J Nanomedicine. 2016,11:5771-5787.

2.Wen Zhao, Yifan Zhang, Xueyun Jiang, Chunying Cui*. Design, synthesis and evaluation of VEG F-siRNA /CRS as a novel vector for gene delivery. Drug Design, Development and Therapy. 2016,10:3851-3865

3.Chunying Cui, Yaonan Wang, Wen Zhao, Kaikai Yang, Xueyun Jiang, Shan Li, Ming Zhao, Yuanbo Song and Shiqi Peng*. RGDS covalently surfaced nanodiamond as a tumor targeting carrier of VEGF-siRNA: synthesis, characterization and bioassay. J. Mater. Chem. B, 2015,39260-9268

4.Chunying Cui, Yuji Wang, Kaikai Yang, Yaonan Wang, Junyu Yang, Jianzhong Xi, Ming Zhao*, Jianhui Wu, and Shiqi Peng*. Preparation and Characterization of RGDS/Nanodiamond as a Vector for VEGF-siRNA Delivery. J. Biomed. Nanotechnol. 2015,11: 70-80

5.Cui Chunying, Wang Y, Wang Y, Zhao M*, Peng S*. Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells. J Anal Methods Chem. 2013;2013:389390. doi: 10.1155/2013/389390. Epub 2013 Apr 4.

6.Cui Chunying, Wang Y, Wang Y, Zhao M*, Peng S*. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. Journal of Analytical Methods in Chemistry Volume  (2013), ttp://dx.doi.org/10.1155/2013/602091

7.Wang F#, Cui Chunying#, Ren Z, Wang L, Liu H, Cui G*. Preparation and biological evaluation of tumor-specific Ara-C liposomal preparations containing RGDV motif. J Pharm Sci. 2012 Dec;101(12):4559-68.

8.Du H#, Cui Chunying#, Wang L, Liu H, Cui G*. Novel Tetrapeptide, RGDF, Mediated Tumor Specific Liposomal Doxorubicin (DOX) Preparations.Mol Pharm. 2011 Aug 1;8(4):1224-32.

9.Chunying Cui, Yunwei Zhang, Lili Wang, Hu Liu and Guohui Cui*. Enhanced anticancer activity of glutamate prodrugs of all-trans retinoic acid. Journal of Pharmacy and Pharmacology 2009; 61: 13531358.

10.Song N, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S*. Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT. Drug Des Devel Ther. 2016 Aug 30;10:2701-11.

11.Lv X, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S*. Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy. Drug Design, Development and Therapy.2016,10:3933-3946

12.Meng Q, Yu X, Li C, Zhang C, Cui C, Luo D*. Possible mechanisms underlying the biphasic regulatory effects of arachidonic acid on Ca2+ signaling in HEK293 cells.Chen L, Cell Signal. 2012 Aug;24(8):1565-72. Epub 2012 Mar 30.

13.Liu Boyang, Chunying, Cui, guohuiCui*. Synthesis and evaluation of anti-tumor activities of N4 fatty acyl amino acid derivatives of 1-beta- arabinofuranosylcytosine. Eur J Med Chem 2009, Sep, 01;44(9):3596-600

14.Wen-Son Hsieh, Ross Soo, Bee-Keow Peh, Thomas Loh, Difeng Dong, Donny Soh, Lim-Soon Wong, Simon Green, Judy Chiao, Chunying Cui, Yoke-Fong Lai, Soo-Chin Lee, Benjamin Mow, Richie Soong, Manuel Salto-Tellez and Boon-Cher Goh*. Pharmacodynamic Effects of Seliciclib (R-Roscovitine, CYC202) in Patients with Undifferentiated Nasopharyngeal Cancer (NPC) Using a Window Trial Design. Cancer research. Clinical Cancer Research. 2009 February 15, 151435

15.Chun-Ying Cui, Wan-Liang Lu, Lan Xiao, Qiang Zhang*. Sublingual Delivery of Insulin: Effects of Enhancers on the Mucosal Lipid Fluidity and Protein Conformation, the Transport, and the In Vivo Hypoglycemic Activity. Biological & Pharmaceutical Bulletin, Vol 28 (12)2279-2288, 2005.

 

主编或副主编的著作/译著

 

重要奖项

1. 首都医科大学2010年第五届青年教师教学基本功比赛(英文组)一等奖

2. 化学生物学与药学院2012年青年教师基本功比赛一等奖

3. 化学生物学与药学院2010年青年教师基本功比赛一等奖

4. 首都医科大学2007年《天职与责任》教工演讲比赛二等奖

 



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