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张筱宜

姓名:张筱宜

性别:女

职称:讲师

 

招生院所:

招生类型:

招生专业:

研究方向名称:天然小分子活性成分研究、计算机辅助药物设计

电子信箱:xiaoyilucky2006@126.com

个人简介

       2007年至今,认真学习医学和生物学知识,实现了自身的化学、生物学、医学、化学生物学和药学的融合。努力把这种融合贯穿于科研之中,使得以计算机辅助的药物设计和基于氨基酸的杂环抗肿瘤先导结构研究快速成长为自己的特色研究领域。参与国家自然科学基金、北京市教委重点项目等科研项目。已发表国外SCI论文29篇,总IF = 103.93;其中第一作者以及共同第一作者论文4篇,IF = 19.521;第二作者论文5篇,IF =16.31

 

教育经历

20109 – 20136月,首都医科大学,药物化学

20079- 20106月,首都医科大学,药物化学

20039- 20076月,首都医科大学,药学

 

工作经历

20139- 至今,首都医科大学,化学生物学与药学院 药物化学系,讲师

20144-20158月,Harbor-UCLA LaBioMed博士后

 

重要学术论文

1.       Xiaoyi Zhang#, Lin Gui#, Xiaoyan Zhang, Stacie L. Bulfer, Valentina Sanghez, Daniel Wong, James Siho Lee, Pei-Yin Shih, Conrad C. Weihl, Henry J. Lin, Michelina Iacovino, Michelle R. Arkin, Yanzhuang Wang, and Tsui-Fen Chou Altered cofactor regulation of p97/VCP ATPase mutants in IBMPFD/ALS Proceedings of the National Academy of Sciences,2015,  E1705–E1714 .(#Co-author)

2.       Lin Gui#, Xiaoyi Zhang#, Kelin Li#, Kevin J. Frankowski#, Shan Li#,Daniel E. Wong, Derek R. Moen,Patrick R. Porubsky,Henry J. Lin, Frank J. Schoenen,and Tsui-Fen Chou]Evaluating p97 Inhibitor Analogues for Potency against p97–p37 and p97–Npl4–Ufd1 Complexes. ChemMedChem, 2016, 11(9): 953–957. IF = 2.98

3.       Chen-Jie Fang#, Lin Gui#, Xiaoyi Zhang#, Derek R. Moen, Kelin Li, Kevin J. Frankowski, Henry J. Lin, Frank J. Schoenen, and Tsui-Fen Chou Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97–p47 Complex. ChemMedChem, 2015, 10(1): 52-56. (#Co-author)

4.       Fengxiang Du, Xiaoyi Zhang, Shan Li, Yaonan Wang, Meiqing Zheng, Yuji Wang, Shurui Zhao, Jianhui Wu, Lin Gui, Ming Zhao, Shiqi Peng, Mechanism of forming trimer, self-assembling nano-particle and inhibiting tumor growth of small molecule CIPPCT, Medicinal Chemistry Communication, 2014,5, 1634-1643 DOI:  10.1039/C4MD00158C.

5.       Xiaoyi Zhang, Yifan Yang, Ming Zhao, Liu Liu, Meiqing Zheng, Yuji Wang, Jianhui Wu, Shiqi Pen. A class of Trp-Trp-AA-OBzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalation-mechanism investigation and 3D QSAR analysis. European Journal of Medicinal Chemistry, 2011, 46, 3410-3419.

6.       Chunyu Li, Xiaoyi Zhang, Ming Zhao, Yuji Wang, Jianhui Wu, Jiawang Liu, Meiqing Zheng, Shiqi Peng. A class of novel N-(1-methyl-b-carboline-3-carbonyl)-N’-(aminoacid-acyl)-hydrazines: Aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis. European Journal of Medicinal Chemistry 2011, 46, 11, 5598–5608.

7.       Xiaoyi Zhang, Wei Wang, Shenling Cheng, Ming Zhao,Meiqing Zheng, Heng Wei Chang, Jianhui Wu, Shiqi Peng. 2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3- carboxylic acids:Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity. Bioorganic Medicinal Chemistry, 2010, 18, 1536–1554.

8.       Jiangyuan Liu, Xiaoyi Zhang, Ming Zhao, Shiqi Peng. Synthesis, Evaluation and 3D QSAR Analysis of Novel Estradiol-RGD Octapeptide Conjugates with Oral Anti-osteoporosis Activity. European Journal of Medicinal Chemistry, 2009, 44, 1689-1704.

9.       Shenling Cheng, Xiaoyi Zhang, Wei Wang, Ming Zhao, Meiqing Zheng, Heng Wei Chang, Jianghui Wu, Shiqi Peng. A Class of Novel N-(3S-1,2,3,4-Tetrahydroisoquinoline-3- carbonyl)-L-amino Acids: Their Synthesis, Antithrombotic Activity Evaluation and 3D QSAR Analysis. European Journal of Medicinal Chemistry, 2009, 44, 4904-4919.

10.    Meiqing Zheng, Xiaoyi Zhang, Ming Zhao, Heng Wei Chang, Wei Wang, Yuji Wang, Shiqi Peng. (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a Class of Novel Anti-thrombotic Agents: Synthesis, Bioassay, 3D QSAR, and ADME Analysis. Bioorganic Medicinal Chemistry, 2008, 16, 9574-9587.

 

和主编或副主编的著作/译著

 

重要奖项

2016年,获得首都医科大学第八届青年教师基本功比赛中文(含双语)授课比赛(基础)三等奖;

 



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