康贵峰

讲师

首都医科大学

药学院

药物化学系

多肽及小分子药物北京市重点实验室

l  教育经历：

2005/8 - 2008/7，北京大学药学院，博士，导师：彭师奇、赵明。

2002/9 - 2005/7，中国科学院山西煤化所，硕士，导师：王建国。

1998/9 - 2002/7，西北大学化学系，学士。

个人简介

 2015年进入多肽及小分子药物北京市重点实验室，任药物化学系讲师。主攻药物化学，有机化学，糖化学，有机金属化学, 多肽，波谱分析，生物化学

l l  工作经历：

2016/1 - 至今，首都医科大学化学生物学院药学院，教师

2014/9 - 2015/12，美国弗吉尼亚联邦大学药物化学系，博士后

2012/4 - 2013/11，北京四环制药，项目经理

2009/12 - 2014/1，浙江大学、浙江医药股份有限公司新昌制药厂联合培养，博士后

2009/12 - 2012/3，浙江医药股份有限公司新昌制药厂，职工

2008/9 - 2009/10，康龙化成（北京）新药技术有限公司，高级研究员

l  代表性科研论文：

1.       Guifeng Kang, Yuji Wang, Jiawang Liu, Jianhui Wu, Ming Zhao, Guochun Li, Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Nathan Mair, Shiqi Peng, Development of three-component conjugates : to get nano-globes with pouous surfaces, high in vivo anti-osteoporosis activity and minimal side effects, J.Mater. Chem.,09/ 2012, 22(40), 21740-21748.

2.       Guifeng Kang, Ming Zhao, Xiaoyi Zhang, Li Peng, Chunbo Li, Wei Mao, Weidong Ye, Shiqi Peng “A class of novel conjugates of substituted purine and Gly-AA-OBzl: Synthesis and evaluation of orally analgesic activity”, Bioorg. Med. Chem. Lett.,10/2010, 20(20), 6157-6160.

3.       Yuji Wang, Guifeng Kang, Jiawang Liu, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Ye Li, Xiaobo Zhong, Yifan Yang, Shiqi Peng, Novel potassium N-[(2S, 3R, 4R, 5R)-2,3,4,5,6-pentahy -droxylhex-1-yl]-L-amino acid dichloroplatinates(II) with high anti-tumor activity and low sideR, 5R)-2,3,4,5,6-pentahydroxylhex-1-yl]-L-amino acid dichloroplatinates() reaction, Metallomics, 04/2012, 4(5), 441-447.

4.       Jinghua Zhao, Guifeng Kang, Wei Wang, Ming Zhao, Xiaoyi Zhang, Chunbo Lu, Wei Mao, Heng Wei Chang, Weidong Ye, Shiqi Peng, N-[2-Chloro-9H-purin-6-yl]-N- cyclopropylgly- cylamino acids and derivatives: Synthesis, evaluation as a class of novel analgesics, and 3D QSAR analysis, Bioorg. Med. Chem., 08/2009, 17 (17), 6305-6310.

5.       Yuji Wang, Guifeng Kang, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Yifan Yang, Jiawang Liu, Shiqi Peng, A new platinum-complex show easy preparation, promising anti-tumor activity, and better efficacy and distribution properties than oxaliplatin, Mol. BioSyst., 12/2011, 7(12), 3245-3252.

6.       Ning Li, Guifeng Kang, Lin Gui, Ming Zhao, Wenjing Wang, Jianwei Zhang, Yan-Feng Yue, Shiqi Peng, Novel Cu(II)-RGD-octapeptides: Synthesis, coordination mode, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and correlation of sequence with nano-structure., Nanomed- Nanotechnol., 01/2011, 7(4), 403-409.

7.       Yuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao, Lin Gui,Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Shiqi Peng, Novel nano-materials RGD-tetrapeptide-modified 17β-amino-11α- hydroxyandrost-1,4-diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation, J.Mater. Chem.,02/2012, 22(11), 4652-4659.

8.       Yuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao, Lin Gui,Ning Li, Li Peng, Xiaoyi Zhang, Li Li, Shiqi Peng, Novel nano-materials RGD-tetrapeptide-modified 17β-amino-11α- hydroxyandrost-1,4-diene-3-one: synthesis, self-assembly based nano-images and in vivo anti-osteoporosis evaluation, J.Mater. Chem.,02/2012, 22(11), 4652-4659.

9.       Jingcheng Tang, Ming Zhao, Yuji Wang, Guifeng Kang, Jianhui Wu, Meiqing Zheng, Shiqi Peng, One single HPLC-PDA/(-)ESI-MS/MS analysis to simultaneously determine 30 components of the aqueous extract of Rabdosia rubescens,  J. Chromatogr. B., 09/2011, 879 (26) 2783-2793.

10.   Jianhui Wu, Lei Wei, Ming Zhao, Yuji Wang, Guifeng Kang, Shiqi Peng, N-[2(3-Carboxyl-9-benzyl-carboline-1-yl)ethyl-1- yl]-amino acids: correlation of spectral property with in vivo anti-tumor activity, Med. Chem. Res., 04/2012, 21(1), 116-123.

11.   Wenjing Wang, Ming Zhao, Yuji Wang, Jiawang Liu, Jianhui Wu, Guifeng Kang and Shiqi Peng, {2-[1-(3-Methoxycarbonylmethyl -1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}- acetic acid methyl ester (MIAM): Its anti-cancer efficacy and intercalation mechanism identified via multi-model systems, Mol. BioSyst., 03/2011, 7(3), 766-772.

l  授权专利：

1.         Shiqi Peng, Ming Zhao, Guohui Cui, Guifeng Kang, ChunBo Lu, Wei Mao,  Weidong Ye, Substituted purine, preparation and use in medicine, CN101497615.

2.         Shiqi Peng, Ming Zhao, Guifeng Kang, Qian Zhang, N-[2 - (3 - acetyl-2 - oxo-2H-pyridin-1 - yl) - acetyl]-L-amino acid, the synthesis method and application, CN102827245.