招生院所：药学院

招生类型：硕士研究生

招生专业：药物分析学

研究方向名称：不对称合成与手性药物，天然产物生物合成途径解析

电子信箱：lidan19@ccmu.edu.cn

个人简介

博士，副教授。主要从事小分子化合物的不对称合成、中药活性成分生物合成途径解析、合成生物学研究。在国际知名期刊发表了30篇高水平SCI文章。其中，以第一作者身份在Nat. Commun.、ACS Catal.、Org. Lett.、Chem. Commun.、Adv. Synth. Catal.等期刊上发表学术论文10篇，并且多篇被选为期刊封面或亮点报道。

教育经历

2010.9-2014.7 兰州大学 药学学士

2014.9-2019.7 兰州大学 生物化学与分子生物学博士

工作经历

2019年至今 首都医科大学，药学院，天然药物学系

重要学术论文：

[1] D. Li, Y. Yang, M. Zhang, L. Wang, Y. Xu, D. Yang*, R. Wang*. Activation of allylic esters in an intramolecular vinylogous kinetic resolution reaction with synergistic magnesium catalysts. Nat. Commun., 2020, 11, 2559. (IF=14.919)

[2] D. Li, M. Zhang, Y. Yang, T. Peng, D. Yang*, W. Gao*, R. Wang*. Desymmetrization Process by Mg(II)-Catalyzed Intramolecular Vinylogous Michael Reaction. Org. Lett., 2020, 22, 9229-9233. (IF=6.555)

[3] D. Li^#, L. Wang^#, H. Zhu, L. Bai, Y. Yang, M. Zhang, D. Yang*, R. Wang*. Catalytic Asymmetric Reactions of α-Isocyanoacetates and meso-Aziridines Mediated by an in-Situ-Generated Magnesium Catalytic Method. Org. Lett., 2019, 21, 4717-4720. (IF=6.555)

[4] D. Li^#, L. Wang^#, Y. Yang, M. Zhang, T. Peng, D. Yang*, R. Wang*. Construction of Optically Active 2H- and 3H-Pyrroles by Cyclization and Chirality Maintaining 1,5-Ester Shift Reactions. Adv. Synth. Catal., 2019, 361, 3744-3750. (IF=5.837)

[5] D. Li, K. Wang, L. Wang, Y. Wang, P. Wang, X. Liu, D. Yang*, R. Wang*. Magnesium Catalysis Mediated Tetrazoles in Desymmetrization Reaction of Aziridines. Org. Lett., 2017, 19, 3211-3214. (IF=6.555)

[6] D. Li, D. Yang*, L. Wang, X. Liu, K. Wang, J. Wang, P. Wang, Y. Liu, H. Zhu, R. Wang*. An Efficient Nickel-Catalyzed Asymmetric Oxazole-Forming Ugi-Type Reaction for the Synthesis of Chiral Aryl-Substituted THIQ Rings. Chem. Eur. J., 2017, 23, 6974-6978. (IF=5.236)

[7] D. Li^#, Y. Wang^#, L. Wang, J. Wang, P. Wang, K. Wang, L. Lin, D. Liu*, X. Jiang*, D. Yang*. Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines. Chem. Commun., 2016, 52, 9640-9643. (IF=6.222)

[8] D. Li^#, L. Wang^#, D. Yang, B. Zhang*, R. Wang*. Catalytic Desymmetrization of meso-Aziridines with Benzofuran-2(3H)-Ones Employing a Simple In Situ-Generated Magnesium Catalyst. ACS Catal., 2015, 5, 7432-7436. (IF=13.084)

[9] D. Li, D. Yang*, L. Wang, X. Liu, X. Jiang*, R. Wang*. Mg^II-Catalyzed Desymmetrization Reaction of meso-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons. Chem. Eur. J., 2016, 22, 17141-17144. (IF=5.236)

[10] L. Wang^#, D. Li^#, D. Yang, K. Wang, J. Wang, P. Wang, W. Su*, R. Wang*. Catalytic Asymmetric Ring-Opening Reactions of Aziridines with 3-Aryl-Oxindoles. Chem. Asian J., 2016, 11, 691-695. (IF=4.568)

[11] Magnesium Catalysis in Asymmetric Synthesis. D. Yang, L. Wang, D. Li, R. Wang*, Chem., 2019, 5, 1108-1166. (IF=22.804)

承担重要项目

1. 2060302-2101-19，集成合成生物学策略及化学-酶法合成策略实现活性天然产物的绿色高效、模块化和规模化合成，课题负责人，中央本级重大增减支项目，200万元，2021.09-2023.12。

2. KM202110025025，新型轴手性吡唑化合物的不对称合成及应用探索，主持，北京市教育委员会科研项目，15万元，2021.01-2023.12。