招生院所：药学院

招生类型：博士研究生、硕士研究生

招生专业：药物分析学（科学学位）

研究方向名称：生物医用传感器研究

电子信箱：xyzhang@ccmu.edu.cn

个人简介

教授，博士生导师。主要研究方向包括：（1）基于纳米电子器件的药物检测分析，即利用功能化固态纳米器件（场效应晶体管、纳米孔等）结合高分子材料修饰技术，应用于超高灵敏度单生物分子及药物等的检测和分析；（2）基于人造细胞膜的药物检测传感器，如利用天然膜蛋白重组于固体支撑高分子膜内的活性表面及纳米反应器，用于选择性高灵敏生物分子检测及分析；（3）功能高分子材料及其生物医用研究，包括特殊浸润性抗菌表面、高强度双网络水凝胶以及电驱动高分子凝胶作为药物载体的制备及药物释放性能研究。相关研究成果发表在Advanced   Materials、Advanced   Functional Materials、Biomaterials、Small、Chemical   Society Review、Advanced   Science等具有影响力的国际学术期刊上，其中以第一作者或通讯作者发表SCI论文16篇，共计发表论文35篇，影响因子>10的文章7篇，被引用达2000余次，已授权国内专利6项，日本专利2项，美国专利1项。作为独立PI主持多个国际/国内科研项目，包括瑞士自然科学基金、欧盟玛丽居丽学者基金，以及中国国家自然科学基金面上项目等。

教育经历

2005.09 - 2010.07 中国科学院化学研究所高分子物理化学博士

2001.09 - 2005.07 浙江大学材料科学与工程学士

工作经历

2022.03 - 至今首都医科大学   教授

2020.09 – 2022.02 清华大学访问研究员

2016.11 – 2021.08 荷兰莱顿大学研究员

2010.08 – 2016.10 瑞士巴塞尔大学高分子物理化学博士后

重要学术论文：

1. Xiaoyan Zhang*,   Tingxian Liu, Aimee Boyle, Azadeh Bahreman, Qiushi Jing, Honglei Xue, Roxanne   Kieltyka, Alexander Kros, Grégory F. Schneider*, Wangyang Fu*,   Dielectric-modulated biosensing with ultrahigh-frequency operated graphene   field-effect transistors,  Advanced Materials , 2022,   34(7), DOI:10.1002/adma.202106666. IF="30.7

2. Nianze Shang, Yi Cheng, Shen Ao,   Gulimire Tuerdi, Mengwen Li, Xiaoyu Wang, Hao Hong, Zehui Li, Xiaoyan   Zhang*, Wangyang Fu*, Kaihui Liu*, Zhongfan Liu*, Graphene photonic   crystal fiber-based fluid sensor toward distributed environmental monitoring,    Acta Physico-Chimica Sinica , 2022, 38, 2108041. IF="2.3

3. Gulimire Tuerdi, Abliz Yimit, Xiaoyan   Zhang*, Exploring optical and electrical gas detection based on   zinc-tetraphenylporphyrin sensitizer,  Analytical Sciences , 2022 ,   DOI: 10.1007/s44211-022-00103-9. IF="2.1

4. Yingqi Huang, Shujia Yin, Yujia   Huang, Xiaoyan Zhang, Weizhe Zhang, Guangya Jiang, Q1 Hongwei Zhu,   Chunlei Wan*, Wangyang Fu*, Graphene oxide/hexylamine superlattice   field-effect biochemical sensors,  Advanced Functional Materials , 2021,   31, 2010563. IF="18.8

5. Chunyu Wang, Yue Shao, Kunfeng   Zhang, Baichun Wu, Xianyuan Du, Xingchun Li, Xiaoyan Zhang, Fuxin   Liang*, Zhenzhong Yang*, Facile approach to fabricate a high-performance   superhydrophobic mesh,  ACS Applied Materials and Interfaces , 2021,   13(13), 15720. IF="9.2

6. Xiaoyan Zhang,   Qige Qi, Qiushi Jing, Shen Ao, Zhihong Zhang, Muhong Wu, Kaihui Liu, Weipeng   Wang, Yunhan Ling, Zhengjun Zhang, Wangyang Fu*, Electrical probing of   COVID-19 spike protein receptor binding domain via a graphene field-effect   transistor,  2020 , arXiv:2003.12529 [physics.app-ph].

7. Xiaoyan   Zhang, Pauline van Deursen, Wangyang Fu*, Grégory F.   Schneider*, Facile and ultraclean graphene-on-glass nanopores by controlled   electrochemical etching,  ACS sensors , 2020, 5(8), 2317–2325.   IF="7.7

8. Xiaoyan Zhang,   Qiushi Jing, Shen Ao, Grégory F. Schneider, Dmitry Kireev, Zhengjun Zhang,   Wangyang Fu*, Ultrasensitive field‐effect biosensors enabled by the unique   electronic properties of graphene,  Small , 2020, 16, 1902820.   IF="13.3

9. Serena Rigo, Chao Cai, Gesine   Gunkel-Grabole, Lionel Maurizi, Xiaoyan   Zhang, Jian Xu, Cornelia G. Palivan, Nanoscience‐based strategies to   engineer antimicrobial surfaces,  Advanced   Science , 2018,   5(5), 1700892. IF="16.8

10. Xiaoyan Zhang, Mihai Lomora, Tomaz Einfalt, Wolfgang Meier,   Noreen Klein, Dirk Schneider, Cornelia G. Palivan*, Active surfaces   engineered by immobilizing protein-polymer nanoreactors for selectively   detecting sugar alcohols,  Biomaterials , 2016,   89, 79. IF="12.5

11. Cornelia   G. Palivan*, Roland Goers, Adrian Najer, Xiaoyan Zhang, Anja Car,   Wolfgang Meier*, Bioinspired polymer vesicles and membranes for biological   and medical applications,  Chemical Society Reviews , 2016 ,    45(2), 377-411. IF="54.5

12. Catherine E. Housecroft, Cornelia G. Palivan, Karl Gademann, Michel   Calame, Viktoria Mikhalevich, Xiaoyan Zhang, Ellen Piel, Mathieu Szponarski, Alexandra Wiesler, Angelo Lanzilotto,   Edwin Constable, Axel Fanget, Palph L. Stoop, ‘Active surfaces’ as possible   functional system in detection and chemical (bio) reaction,  CHIMIA   International Journal for Chemistry , 2016, 70(6), 402-412. IF="1.5

13. Justyna Kowal^#,   Xiaoyan Zhang^# (co-first author), Ionel   Adrian Dinu, Cornelia G. Palivan and Wolfgang Meier, Planar biomimetic   membranes based on amphiphilic block bopolymer,  ACS Macro Letters , 2014,   3, 59-63. IF="6.9

14. Xiaoyan Zhang, Wangyang Fu, Cornelia G. Palivan*, Wolfgang   Meier*, Natural channel proteins inserts and functions in a completely   artificial, solid-supported bilayer membrane,  Scientific Reports ,   2013, 3, 2196. IF="4.4

15. Xiaoyan Zhang, Wangyang Fu, Chunting Duan, Hong Xiao,   Meiwu Shi, Ning Zhao*, Jian Xu*, Superhydrophobicity determines the buoyancy   performance of kapok fiber aggregates,  Applied Surface Science , 2013, 266, 225. IF="6.7

16. Cornelia G. Palivan*, Xiaoyan Zhang, Wolfgang Meier*,   Protein–polymer supramolecular assemblies: a key combination for   multifunctionality,  Chimia , 2013, 87, 791-795. IF="1.5

17. Christoph   Edlinger, Xiaoyan Zhang, Ozana   Fischer-Onaca, Cornelia G. Palivan, Polymer nanoreactors,  Encyclopedia of polymer science and   technology , 2013,   581.

18. Chunting Duan, Ning Zhao*,   Xiaolan Yu, Xiaoyan Zhang, Jian   Xu*, Chemically modified kapok fiber for fast adsorption of Pb2+, Cd2+, Cu2+   from aqueous solution,  Cellulose ,   2013, 20(2), 849–860. IF="5.0

19. Xiaoyan Zhang, Pascal Tanner, Alex Graff, Cornelia Palivan*,   Wolfgang Meier, Mimicking the cell membrane with block copolymer membranes,  Journal of Polymer Science, Part A: Polymer   Chemistry , 2012, 50(12), 2293. IF="2.7

20. Etienne   Cabane^#, Xiaoyan   Zhang^# (co-first   author), Karolina   Langowska, Cornelia Palivan*, Wolfgang Meier, Stimuli-responsive polymers and   their applications in nanomedicine,  Biointerphases , 2012,   7(1-4), 9. IF="2.5

21. Haosen Fan, Xiaolan Yu, Yuhua   Long, Xiaoyan Zhang, Haifan Xiang,   Chunting Duan, Ning Zhao, Xiaoli Zhang, Jian Xu*, Preparation of   kapok–polyacrylonitrile core–shell composite microtube and its application as   gold nanoparticles carrier.  Applied   Surface Science , 2012,   258, 2876-2882. IF="6.7

22. Xiaoyan Zhang,   Yanfang Li, Shuguang Yang, Ning Zhao, Lianghe Shi, Hong Xiao, Meiwu Shi,   Xiaoli Zhang, Jian Xu*, Facile fabrication of large scale microtubes with a   natural template—kapok fiber,  Chinese Journal of Polymer Science , 2010, 28(5),   841. IF="3.6

23. Liang Zhang, Xiaoyan Zhang, Zhen Dai, Junjie Wu, Ning Zhao, Jian Xu*,   Micro-nano hierarchically structured nylon 66 surfaces with unique   wettability,  Journal of Colloid   and Interface Science , 2010,   345, 116-119. IF="8.1

24. Junjie Wu, Songmiao Liang,   Hongjun Dai, Xiaoyan Zhang,   Xiaolan Yu, Yuanli Cai, Lina Zhang, Ning Wen, Bin Jiang, Jian Xu*, Structure   and properties of cellulose/chitin blended hydrogel membranes fabricated via   a solution pre-gelation technique,  Carbohydrate   Polymers , 2010, 79,   677-684. IF="9.4

25. Xiaoyan Zhang,   Xinglin Guo, Shuguang Yang, Shuaixia Tan, Xiaofeng Li, Hongjun Dai, Xiaolan   Yu, Xiaoli Zhang, Ning Weng, Bin Jian, Jian Xu*, A double-network hydrogel   with high mechanical strength prepared by two biocompatible polymers,  Journal   of Applied Polymer Science , 2009, 112(15), 3063. IF="3.1

26. Xiaofeng Li, Hongjun Da, Shuaixia   Tan, Xiaoyan Zhang, Haiyun Liu,   Yongxin Wang, Ning Zhao, Jian Xu*, Facile preparation of poly(ethyl   a-cyanoacrylate) superhydrophobic and gradient wetting surfaces,  Journal of Colloid and Interface Science ,   2009, 340, 93–97. IF="8.1

27. Xiaoyan Zhang,   Ning Zhao, Songmiao Liang, Xiaoying Lu, Xiaofeng Li, Qiongdan Xie, Xiaoli   Zhang, Jian Xu*, Facile creation of biomimetic systems at the interface and   in bulk,  Advanced Materials , 2008, 20, 2938. IF="30.7

28. Ning Zhao, Xiaoyan Zhang,   Xiaoli Zhang, Jian Xu*, Simultaneous tuning chemical composition and   topography of copolymer surface: micelles as the building blocks,  ChemPhysChem , 2007, 8, 1108-1114. IF="3.1

29. Ning   Zhao, Xiaoyan   Zhang, Yanfang Li, Xiaoying Lu, Silu Sheng, Xiaoli Zhang, Jian Xu*, A   self-organized polymer aggregates with a biomimetic hierarchical structure   and its superhydrophobic effect,  Cell   Biochemistry and Biophysics , 2007,   49, 91-97. IF="2.2

30. Shuaixia   Tan,   Xiaoyan Zhang, Ning Zhao, Xinglin   Guo, Xiaoli Zhang, Jian Xu*,   Simulation of sessile water-droplet evaporation on superhydrophobic surfaces,    Chinese Journal of Chemical Physics ,   2007, 20(2), 140-144. IF="1.1

31. Ning Zhao, Xiaoying Lu, Xiaoyan Zhang, Shuaixia Tan, Haiyun Liu,   Jian Xu*, Progress in superhydrophobic surfaces,  Progress   in Chemistry ,   2007, 19, 860. IF="1.2

32. Shuguang Yang, Yongjun Zhang, Xiaoyan Zhang, Ying Guan, Jian Xu*, Xiaoli   Zhang, From cloudy to transparent: chain rearrangement in hydrogen-bonded   assembly film,  ChemPhysChem ,   2007, 8, 418-424. IF="3.1

33. Xiaoyan Zhang,   Shuaixia Tan, Ning Zhao, Xinglin Guo, Xiaoli Zhang, Yongjun Zhang, Jian Xu*,   Evaporation of sessile water-droplet on natural lotus and biomimetic polymer   surface with superhydrophobicity,  ChemPhysChem , 2006,   7(10), 2067. IF="3.1

34. Ning Zhao, Lihui Weng,   Xiaoyan Zhang, Qiongdan Xie, Xiaoli Zhang, Jian Xu*, A lotus-leaf-like   superhydrophobic surface prepared by solvent-induced crystallization,  ChemPhysChem , 2006, 7, 824-827. IF="3.1

35. Ning Zhao, Qiongdan Xie, Lihui   Weng, Shengqing Wang, Xiaoyan Zhang,   Jian Xu*, Superhydrophobic surface from vapor-induced phase separation of   copolymer micellar solution,  Macromolecules , 2005,  38,    8996-8999. IF="5.9

承担重要项目

1. 52173007，基于Janus磁性蛋白复合体调控仿细胞膜定向传输及开关功能的研究，国家自然科学基金，面上项目，58万元（2022.01-2025.12）

2. 20212001392，清华大学，技术服务项目，生物化学传感器的测试与优化，40万元，（2021.09-2022.03）

3. 749671，Advanced graphene   nanodevices with functional hydrogels for DNA sequencing，European Commission，Marie-Skłodowska-Curie   Individual Fellowship，192599 Euro（2018.10-2020.08）

4. P300P2-164663，Slowing down DNA   translocation through graphene nanopore with functional hydrogel，Swiss National Science   Foundation，Advanced Postdoc.Mobility Fellowship，98400 Swiss Franc（2016.11-2018.09）

重要奖项

1. 张晓艳，玛丽居里学者，国家级，择优，欧洲学术委员会，2017

2. 张晓艳，APM学者，国家级，择优，瑞士国家科学基金委员会，2016

3. 张晓艳，北京市“海聚工程”，省部级，全职项目，北京市教育委员会，2022